Due to their fundamental role in energy production, mitochondria have been traditionally
known as the powerhouse of the cell. Recent discoveries have suggested crucial roles of …

Stem cell aging and exhaustion are considered important drivers of organismal aging. Age-associated
declines in stem cell function are characterized by metabolic and epigenetic …

The discovery of induced pluripotent stem cells (iPSCs) a decade ago, which we are celebrating
in this issue of Cell, represents a landmark discovery in biomedical research. Together …

Aging is the major risk factor for many human diseases. In vitro studies have demonstrated
that cellular reprogramming to pluripotency reverses cellular age, but alteration of the aging …

We conducted preregistered replications of 28 classic and contemporary published findings,
with protocols that were peer reviewed in advance, to examine variation in effect …

Interspecies blastocyst complementation enables organ-specific enrichment of xenogenic
pluripotent stem cell (PSC) derivatives. Here, we establish a versatile blastocyst …

INTRODUCTION Pluto was discovered in 1930 and was long thought to be a misfit or
anomaly in the solar system. However, the 1992 discovery of the Kuiper Belt—a torus-shaped …

The COVID-19 pandemic represents a major global health crisis that continues to threaten
public health and safety. Although the pandemic is still unfolding, measures to reduce the …

Reflectance spectra in the 1- to 2.5-micrometer wavelength region of the surface of Europa
obtained by Galileo's Near Infrared Mapping Spectrometer exhibit distorted water absorption …

Patients with multiple sclerosis acquire disability either through relapse-associated worsening
(RAW) or progression independent of relapse activity (PIRA). This study addresses the …