Significance: Iron and oxygen are intimately linked: iron is an essential nutrient utilized as a
cofactor in enzymes for oxygen transport, oxidative phosphorylation, and metabolite …

Reprogramming of cellular energy metabolism is widely accepted to be one of the main
hallmarks of cancer. The aberrant expression pattern of key regulators in the glycolysis pathway …

Methodologies to detect DNA sequences with high sensitivity and specificity have tremendous
potential as molecular diagnostic agents. Most current methods exploit the ability of single-…

Enhancing the intracellular labile iron pool (LIP) represents a powerful, yet untapped
strategy for driving ferroptotic death of cancer cells. Here, we show that NRF2 maintains iron …

Myeloid malignancies, including acute myeloid leukaemia (AML), arise from the expansion
of haematopoietic stem and progenitor cells that acquire somatic mutations. Bulk molecular …

Opisthorchis viverrini–related cholangiocarcinoma (CCA), a fatal bile duct cancer, is a major
public health concern in areas endemic for this parasite. We report here whole-exome …

Fumarate hydratase (FH) mutation causes hereditary type 2 papillary renal cell carcinoma (PRCC2).
The main effect of FH mutation is fumarate accumulation. The current paradigm …

The accuracy of Reynolds averaged Navier–Stokes (RANS) turbulence models in predicting
complex flows with separation is examined. The unsteady flow around square cylinder and …

Single-cell RNA sequencing (scRNA-seq) is the leading technique for characterizing the
transcriptomes of individual cells in a sample. The latest protocols are scalable to thousands of …

Overexpression of epidermal growth factor receptor (EGFR) is observed in many cancers,
sometimes accompanied by gene amplification. Recently, several clinical therapies targeting …