Directionally tuned signalling in starburst amacrine cell (SAC) dendrites lies at the heart of
the circuit that detects the direction of moving stimuli in the mammalian retina. The relative …

Myelin plasticity occurs when newly formed and pre-existing oligodendrocytes remodel
existing patterns of myelination. Myelin remodeling occurs in response to changes in neuronal …

In pursuit of the goal to understand and eventually reproduce the diverse functions of the
brain, a key challenge lies in reverse engineering the peculiar biology-based “technology” that …

Antagonistic interactions between center and surround receptive field (RF) components lie
at the heart of the computations performed in the visual system. Circularly symmetric center-…

Dendrites in many neurons actively compute information. In retinal starburst amacrine cells,
transformations from synaptic input to output occur within individual dendrites and mediate …

Tuft dendrites of layer 5 pyramidal neurons form specialized compartments important for motor
learning and performance, yet their computational capabilities remain unclear. Structural-…

The voltage clamp technique is frequently used to examine the strength and composition of
synaptic input to neurons. Even accounting for imperfect voltage control of the entire cell …

10.7554/eLife.38446.001 The piriform cortex (PCx) receives direct input from the olfactory
bulb (OB) and is the brain's main station for odor recognition and memory. The transformation …

The brain operates surprisingly well despite the noisy nature of individual neurons. The
central mechanism for noise mitigation in the nervous system is thought to involve averaging …

Feedforward (FF) inhibition is a common motif in many neural networks. Typically, excitatory
inputs drive both principal neurons and interneurons; the interneurons then inhibit the …