The liver is one of the richest organs in terms of number and density of mitochondria. Most
chronic liver diseases are associated with the accumulation of damaged mitochondria. …

INTRODUCTION Most cancer patients die from cancer that recurs after spreading to a different
tissue, rather than from their original tumor. After successful treatment of the original tumor…

Introduction: Liver X receptors (LXR) are transcription factors that belong to the nuclear
receptor superfamily. Natural derivatives of cholesterol, known as oxysterols, have been …

After a brief historical survey, the structure, main methods of preparation and reactivity of β-lactones
are examined with emphasis on developments since 1980. The structure of β-…

INTRODUCTION Pancreatic ductal adenocarcinoma (PDA) is the fourth most common cause
of death from cancer worldwide and has a 5-year survival rate of 6%. Patients who have …

Cholesterol is a structural component of lipid rafts within the plasma membrane. These domains,
used as platforms for various signaling molecules, regulate cellular processes including …

Glycosylation alterations are indicative of tissue inflammation and neoplasia, but whether
these alterations contribute to disease pathogenesis is largely unknown. To study the role of …

Melt generated by mantle upwelling is fundamental to the production of new oceanic crust
at mid-ocean ridges, yet the forces controlling this process are debated 1 , 2 . Passive-flow …

Purpose: The aim of the study was to investigate the vascular and stromal architecture of
preclinical tumor models and patient tumor specimens from malignancies with known clinical …

Abstract Analysis of lunar laser ranging and seismic data has yielded evidence that has been
interpreted to indicate a molten zone in the lowermost mantle overlying a fluid core. Such a …