Genome-wide association study identifies eight loci associated with blood pressure
…, MI McCarthy, PF O'Reilly, L Peltonen, A Pouta… - Nature …, 2009 - nature.com
Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide.
To date, identification of common genetic variants influencing blood pressure has proven …
To date, identification of common genetic variants influencing blood pressure has proven …
Common variants near MC4R are associated with fat mass, weight and risk of obesity
…, CNA Palmer, K Papadakis, S Potter, A Pouta… - Nature …, 2008 - nature.com
To identify common variants influencing body mass index (BMI), we analyzed genome-wide
association data from 16,876 individuals of European descent. After previously reported …
association data from 16,876 individuals of European descent. After previously reported …
[HTML][HTML] Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts
…, M Dunlop, BD Mitchell, KH Herzig, A Pouta… - PLoS …, 2013 - journals.plos.org
Background Obesity is associated with vitamin D deficiency, and both are areas of active
public health concern. We explored the causality and direction of the relationship between …
public health concern. We explored the causality and direction of the relationship between …
Identification of seven loci affecting mean telomere length and their association with disease
Interindividual variation in mean leukocyte telomere length (LTL) is associated with cancer
and several age-associated diseases. We report here a genome-wide meta-analysis of …
and several age-associated diseases. We report here a genome-wide meta-analysis of …
Common variants associated with plasma triglycerides and risk for coronary artery disease
Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in
epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery …
epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery …
Variants in MTNR1B influence fasting glucose levels
…, AD Morris, S Naitza, M Orrù, CNA Palmer, A Pouta… - Nature …, 2009 - nature.com
To identify previously unknown genetic loci associated with fasting glucose concentrations,
we examined the leading association signals in ten genome-wide association scans …
we examined the leading association signals in ten genome-wide association scans …
Sequence variants at CHRNB3–CHRNA6 and CYP2A6 affect smoking behavior
…, M Perola, J Kettunen, AL Hartikainen, A Pouta… - Nature …, 2010 - nature.com
Smoking is a common risk factor for many diseases 1 . We conducted genome-wide
association meta-analyses for the number of cigarettes smoked per day (CPD) in smokers (n = …
association meta-analyses for the number of cigarettes smoked per day (CPD) in smokers (n = …
Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human
Free fatty acids provide an important energy source as nutrients, and act as signalling
molecules in various cellular processes 1 , 2 , 3 , 4 . Several G-protein-coupled receptors have …
molecules in various cellular processes 1 , 2 , 3 , 4 . Several G-protein-coupled receptors have …
Genome-wide association study identifies five loci associated with lung function
Pulmonary function measures are heritable traits that predict morbidity and mortality and
define chronic obstructive pulmonary disease (COPD). We tested genome-wide association …
define chronic obstructive pulmonary disease (COPD). We tested genome-wide association …
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche
…, J Peto, PDP Pharoah, DS Postma, A Pouta… - Nature, 2014 - nature.com
Age at menarche is a marker of timing of puberty in females. It varies widely between
individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, …
individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, …