Immune-related adverse events of checkpoint inhibitors
…, O Lambotte, X Mariette, A Prat… - Nature reviews Disease …, 2020 - nature.com
Cancer immunotherapies have changed the landscape of cancer treatment during the past
few decades. Among them, immune checkpoint inhibitors, which target PD-1, PD-L1 and …
few decades. Among them, immune checkpoint inhibitors, which target PD-1, PD-L1 and …
The blood–brain barrier
R Daneman, A Prat - Cold Spring Harbor perspectives in …, 2015 - cshperspectives.cshlp.org
Blood vessels are critical to deliver oxygen and nutrients to all of the tissues and organs
throughout the body. The blood vessels that vascularize the central nervous system (CNS) …
throughout the body. The blood vessels that vascularize the central nervous system (CNS) …
[HTML][HTML] Customizing local and systemic therapies for women with early breast cancer: the St. Gallen International Consensus Guidelines for treatment of early breast …
…, A Partridge, M Piccart, P Poortmans, A Prat… - Annals of oncology, 2021 - Elsevier
The 17th St Gallen International Breast Cancer Consensus Conference in 2021 was held
virtually, owing to the global COVID-19 pandemic. More than 3300 participants took part in this …
virtually, owing to the global COVID-19 pandemic. More than 3300 participants took part in this …
[HTML][HTML] Trastuzumab deruxtecan in previously treated HER2-low advanced breast cancer
…, J Tsurutani, NT Ueno, A Prat… - … England Journal of …, 2022 - Mass Medical Soc
Background Among breast cancers without human epidermal growth factor receptor 2 (HER2)
amplification, overexpression, or both, a large proportion express low levels of HER2 that …
amplification, overexpression, or both, a large proportion express low levels of HER2 that …
Mutations in PCSK9 cause autosomal dominant hypercholesterolemia
…, JM Lecerf, G Luc, P Moulin, J Weissenbach, A Prat… - Nature …, 2003 - nature.com
Autosomal dominant hypercholesterolemia (ADH; OMIM144400), a risk factor for coronary
heart disease, is characterized by an increase in low-density lipoprotein cholesterol levels …
heart disease, is characterized by an increase in low-density lipoprotein cholesterol levels …
4th ESO–ESMO international consensus guidelines for advanced breast cancer (ABC 4)
Advanced Breast Cancer (ABC) comprises both locally advanced breast cancer (LABC) and
metastatic breast cancer (MBC)[1]. Although treatable, MBC remains virtually an incurable …
metastatic breast cancer (MBC)[1]. Although treatable, MBC remains virtually an incurable …
[HTML][HTML] Registry of transcatheter aortic-valve implantation in high-risk patients
…, A Leguerrier, M Lievre, A Prat… - … England Journal of …, 2012 - Mass Medical Soc
Background Transcatheter aortic-valve implantation (TAVI) is an emerging intervention for
the treatment of high-risk patients with severe aortic stenosis and coexisting illnesses. We …
the treatment of high-risk patients with severe aortic stenosis and coexisting illnesses. We …
The wrong kind of transparency
A Prat - American economic review, 2005 - pubs.aeaweb.org
There is a widespread perception, especially among economists, that agency relationships
should be as transparent as possible. By transparency, we mean the ability of the principal to …
should be as transparent as possible. By transparency, we mean the ability of the principal to …
[HTML][HTML] Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer
Introduction In breast cancer, gene expression analyses have defined five tumor subtypes (luminal
A, luminal B, HER2-enriched, basal-like and claudin-low), each of which has unique …
A, luminal B, HER2-enriched, basal-like and claudin-low), each of which has unique …
Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation
T H 17 lymphocytes appear to be essential in the pathogenesis of numerous inflammatory
diseases. We demonstrate here the expression of IL-17 and IL-22 receptors on blood-brain …
diseases. We demonstrate here the expression of IL-17 and IL-22 receptors on blood-brain …