The majority of newly diagnosed prostate cancers are slow growing, with a long natural life
history. Yet a subset can metastasize with lethal consequences. We reconstructed the …

New technologies and analysis methods are enabling genomic structural variants (SVs) to
be detected with ever-increasing accuracy, resolution and comprehensiveness. To help …

Based on transcriptomic analyses of thousands of samples from The Cancer Genome Atlas,
we report that expression of constitutive proteasome (CP) genes (PSMB5, PSMB6, PSMB7) …

Oncogenesis is driven by germline, environmental and stochastic factors. It is unknown how
these interact to produce the molecular phenotypes of tumors. We therefore quantified the …

New technologies and analysis methods are enabling genomic structural variants (SVs) to
be detected with ever-increasing accuracy, resolution, and comprehensiveness. Translating …

Acute megakaryoblastic leukemia (AMKL) is a rare, developmentally restricted, and highly
lethal cancer of early childhood. The paucity and hypocellularity (due to myelofibrosis) of …

Acute megakaryoblastic leukemia (AMKL) represents ∼10% of pediatric acute myeloid
leukemia cases and typically affects young children (<3 years of age). It remains plagued with …

By regulating protein degradation, constitutive proteasomes (CPs) control practically all cellular
functions. In addition to CPs, vertebrates express immunoproteasomes (IPs). The major …

T cell development depends on sequential interactions of thymocytes with cortical thymic
epithelial cells (cTECs) and medullary thymic epithelial cells. PSMB11 is a catalytic …

The molecular hallmark of childhood acute lymphoblastic leukemia (ALL) is characterized
by recurrent, prognostic genetic alterations, many of which are cryptic by conventional …