User profiles for A. Santos Lopez

Alfonso Santos-Lopez

Junior Leader "La Caixa". Centro Nacional de Biotecnologia
Verified email at cnb.csic.es
Cited by 716

Evolutionary pathways to antibiotic resistance are dependent upon environmental structure and bacterial lifestyle

A Santos-Lopez, CW Marshall, MR Scribner, DJ Snyder… - Elife, 2019 - elifesciences.org
10.7554/eLife.47612.001 Bacterial populations vary in their stress tolerance and population
structure depending upon whether growth occurs in well-mixed or structured environments. …

Small-plasmid-mediated antibiotic resistance is enhanced by increases in plasmid copy number and bacterial fitness

A San Millan, A Santos-Lopez… - Antimicrobial agents …, 2015 - Am Soc Microbiol
Plasmids play a key role in the horizontal spread of antibiotic resistance determinants among
bacterial pathogens. When an antibiotic resistance plasmid arrives in a new bacterial host, …

Within-patient evolution of plasmid-mediated antimicrobial resistance

…, L Toribio-Celestino, A Santos-Lopez… - Nature ecology & …, 2022 - nature.com
Antimicrobial resistance (AMR) in bacteria is a major threat to public health; one of the key
elements in the spread and evolution of AMR in clinical pathogens is the transfer of …

Polymyxin Resistance Caused by mgrB Inactivation Is Not Associated with Significant Biological Cost in Klebsiella pneumoniae

A Cannatelli, A Santos-Lopez, T Giani… - Antimicrobial agents …, 2015 - Am Soc Microbiol
The inactivation of the mgrB gene, which encodes a negative-feedback regulator of the
PhoPQ signaling system, was recently shown to be a common mutational mechanism …

Parallel evolution of tobramycin resistance across species and environments

MR Scribner, A Santos-Lopez, CW Marshall, C Deitrick… - MBio, 2020 - Am Soc Microbiol
Different species exposed to a common stress may adapt by mutations in shared pathways
or in unique systems, depending on how past environments have molded their genomes. …

The roles of history, chance, and natural selection in the evolution of antibiotic resistance

A Santos-Lopez, CW Marshall, AL Haas, C Turner… - Elife, 2021 - elifesciences.org
History, chance, and selection are the fundamental factors that drive and constrain evolution.
We designed evolution experiments to disentangle and quantify effects of these forces on …

Fitness cost and interference of Arm/Rmt aminoglycoside resistance with the RsmF housekeeping methyltransferases

…, A Santos-Lopez, D Thomas-Lopez… - Antimicrobial agents …, 2012 - Am Soc Microbiol
Arm/Rmt methyltransferases have emerged recently in pathogenic bacteria as enzymes that
confer high-level resistance to 4,6-disubstituted aminoglycosides through methylation of the …

Pseudomonas aeruginosa interstrain dynamics and selection of hyperbiofilm mutants during a chronic infection

…, D Snyder, GR Lewin, JS Harris, A Santos-Lopez… - MBio, 2019 - Am Soc Microbiol
Opportunistic pathogens establishing new infections experience strong selection to adapt,
often favoring mutants that persist. Capturing this initial dynamic is critical for identifying the …

Klebsiella pneumoniae sequence type 11 from companion animals bearing ArmA methyltransferase, DHA-1 β-lactamase, and QnrB4

…, A Santos-Lopez, D Thomas-Lopez… - Antimicrobial agents …, 2013 - Am Soc Microbiol
Seven Klebsiella pneumoniae isolates from dogs and cats in Spain were found to be highly
resistant to aminoglycosides, and ArmA methyltransferase was responsible for this …

Novel bla ROB-1-Bearing Plasmid Conferring Resistance to β-Lactams in Haemophilus parasuis Isolates from Healthy Weaning Pigs

J Moleres, A Santos-López, I Lázaro… - Applied and …, 2015 - Am Soc Microbiol
Haemophilus parasuis , the causative agent of Glässer's disease, is one of the early colonizers
of the nasal mucosa of piglets. It is prevalent in swine herds, and lesions associated with …