User profiles for A. Santos Lopez
Alfonso Santos-LopezJunior Leader "La Caixa". Centro Nacional de Biotecnologia Verified email at cnb.csic.es Cited by 716 |
Evolutionary pathways to antibiotic resistance are dependent upon environmental structure and bacterial lifestyle
10.7554/eLife.47612.001 Bacterial populations vary in their stress tolerance and population
structure depending upon whether growth occurs in well-mixed or structured environments. …
structure depending upon whether growth occurs in well-mixed or structured environments. …
Small-plasmid-mediated antibiotic resistance is enhanced by increases in plasmid copy number and bacterial fitness
A San Millan, A Santos-Lopez… - Antimicrobial agents …, 2015 - Am Soc Microbiol
Plasmids play a key role in the horizontal spread of antibiotic resistance determinants among
bacterial pathogens. When an antibiotic resistance plasmid arrives in a new bacterial host, …
bacterial pathogens. When an antibiotic resistance plasmid arrives in a new bacterial host, …
Within-patient evolution of plasmid-mediated antimicrobial resistance
…, L Toribio-Celestino, A Santos-Lopez… - Nature ecology & …, 2022 - nature.com
Antimicrobial resistance (AMR) in bacteria is a major threat to public health; one of the key
elements in the spread and evolution of AMR in clinical pathogens is the transfer of …
elements in the spread and evolution of AMR in clinical pathogens is the transfer of …
Polymyxin Resistance Caused by mgrB Inactivation Is Not Associated with Significant Biological Cost in Klebsiella pneumoniae
A Cannatelli, A Santos-Lopez, T Giani… - Antimicrobial agents …, 2015 - Am Soc Microbiol
The inactivation of the mgrB gene, which encodes a negative-feedback regulator of the
PhoPQ signaling system, was recently shown to be a common mutational mechanism …
PhoPQ signaling system, was recently shown to be a common mutational mechanism …
Parallel evolution of tobramycin resistance across species and environments
Different species exposed to a common stress may adapt by mutations in shared pathways
or in unique systems, depending on how past environments have molded their genomes. …
or in unique systems, depending on how past environments have molded their genomes. …
The roles of history, chance, and natural selection in the evolution of antibiotic resistance
History, chance, and selection are the fundamental factors that drive and constrain evolution.
We designed evolution experiments to disentangle and quantify effects of these forces on …
We designed evolution experiments to disentangle and quantify effects of these forces on …
Fitness cost and interference of Arm/Rmt aminoglycoside resistance with the RsmF housekeeping methyltransferases
…, A Santos-Lopez, D Thomas-Lopez… - Antimicrobial agents …, 2012 - Am Soc Microbiol
Arm/Rmt methyltransferases have emerged recently in pathogenic bacteria as enzymes that
confer high-level resistance to 4,6-disubstituted aminoglycosides through methylation of the …
confer high-level resistance to 4,6-disubstituted aminoglycosides through methylation of the …
Pseudomonas aeruginosa interstrain dynamics and selection of hyperbiofilm mutants during a chronic infection
Opportunistic pathogens establishing new infections experience strong selection to adapt,
often favoring mutants that persist. Capturing this initial dynamic is critical for identifying the …
often favoring mutants that persist. Capturing this initial dynamic is critical for identifying the …
Klebsiella pneumoniae sequence type 11 from companion animals bearing ArmA methyltransferase, DHA-1 β-lactamase, and QnrB4
…, A Santos-Lopez, D Thomas-Lopez… - Antimicrobial agents …, 2013 - Am Soc Microbiol
Seven Klebsiella pneumoniae isolates from dogs and cats in Spain were found to be highly
resistant to aminoglycosides, and ArmA methyltransferase was responsible for this …
resistant to aminoglycosides, and ArmA methyltransferase was responsible for this …
Novel bla ROB-1-Bearing Plasmid Conferring Resistance to β-Lactams in Haemophilus parasuis Isolates from Healthy Weaning Pigs
J Moleres, A Santos-López, I Lázaro… - Applied and …, 2015 - Am Soc Microbiol
Haemophilus parasuis , the causative agent of Glässer's disease, is one of the early colonizers
of the nasal mucosa of piglets. It is prevalent in swine herds, and lesions associated with …
of the nasal mucosa of piglets. It is prevalent in swine herds, and lesions associated with …