Understanding how normally soluble peptides and proteins aggregate to form amyloid fibrils
is central to many areas of modern biomolecular science, ranging from the development of …

Mutations in the gene encoding the enzyme tafazzin, TAZ, cause Barth syndrome (BTHS).
Individuals with this X-linked multisystem disorder present cardiomyopathy (CM) (often dilated)…

The formation of amyloid fibrils is a general class of protein self-assembly behaviour, which
is associated with both functional biology and the development of a number of disorders, …

Oligomeric species populated during the aggregation of the Aβ42 peptide have been
identified as potent cytotoxins linked to Alzheimer’s disease, but the fundamental molecular …

The endosomal sorting complex required for transport-III (ESCRT-III) catalyzes membrane
fission from within membrane necks, a process that is essential for many cellular functions, …

Recent studies aimed at investigating artificial analogs of bacterial colonies have shown
that low-density suspensions of self-propelled particles confined in two dimensions can …

Protein oligomers have been implicated as toxic agents in a wide range of amyloid-related
diseases. However, it has remained unsolved whether the oligomers are a necessary step in …

10.7554/eLife.30292.001 Eukaryotic cells are densely packed with macromolecular
complexes and intertwining organelles, continually transported and reshaped. Intriguingly, …

Mapping free-energy landscapes has proved to be a powerful tool for studying reaction
mechanisms. Many complex biomolecular assembly processes, however, have remained …

Using computer simulations, we show that lipid membranes can mediate linear aggregation
of spherical nanoparticles binding to it for a wide range of biologically relevant bending …