Macrophages have a key role in shaping the tumour microenvironment (TME), tumour
immunity and response to immunotherapy, which makes them an important target for cancer …

Squamous cell carcinomas (SCCs) are heterogeneous tumors sustained by tumor-propagating
cancer cells (TPCs). SCCs frequently resist chemotherapy through still unknown …

Aberrant activation of Wnt signaling is involved in the development of several epithelial
tumors. Wnt signaling includes two major types of pathways: (i) the canonical or Wnt/β-catenin …

The presence of differentiated thyroid cells in thyroid cancer is critical for the antitumor
response to radioactive iodide treatment, and loss of the differentiated phenotype is a key …

Although the principles that balance stem cell self-renewal and differentiation in normal tissue
homeostasis are beginning to emerge, it is still unclear whether cancer cells with tumour …

Head and neck squamous cell carcinomas (HNSCCs) are the eighth most common cancers
worldwide. While promising new therapies are emerging, cisplatin-based chemotherapy …

Mutations in ß-catenin are traditionally described as late events in thyroid cancer progression.
However, the functional implications of ß-catenin dysregulation in the context of tumor …

The Wnt/β-catenin pathway has been associated with thyroid cell growth and tumorigenesis.
However, little is known regarding its involvement in the response to the key regulators of …

Background The transcription factor Pax8 is essential for the differentiation of thyroid cells.
However, there are few data on genes transcriptionally regulated by Pax8 other than thyroid-…

Basal tumor propagating cells (TPCs) control squamous cell carcinoma (SCC) growth by self-renewing
and differentiating into supra-basal SCC cells, which lack proliferative potential. …