The SARS-CoV-2 non-structural protein 1 (Nsp1), also referred to as the host shutoff factor,
suppresses host innate immune functions. By combining cryo-electron microscopy and …

Programmed ribosomal frameshifting is a key event during translation of the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA genome that allows synthesis of the …

The nascent polypeptide–associated complex (NAC) interacts with newly synthesized proteins
at the ribosomal tunnel exit and competes with the signal recognition particle (SRP) to …

The protein kinase mammalian target of rapamycin (mTOR) is the central regulator of cell
growth. Aberrant mTOR signaling is linked to cancer, diabetes, and neurological disorders. …

N-terminal methionine excision from newly synthesized proteins, catalyzed cotranslationally
by methionine aminopeptidases (METAPs), is an essential and universally conserved …

Nonstructural protein 1 (Nsp1) produced by coronaviruses inhibits host protein synthesis. The
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Nsp1 C-terminal domain …

The genetic code that specifies the identity of amino acids incorporated into proteins during
protein synthesis is almost universally conserved. Mitochondrial genomes feature deviations …

Mitochondrial ribosomes (mitoribosomes) are large ribonucleoprotein complexes that
synthesize proteins encoded by the mitochondrial genome. An extensive cellular machinery …

The mitochondrial translation system originates from a bacterial ancestor but has substantially
diverged in the course of evolution. Here, we use single-particle cryo-electron microscopy …

Significance: The tricarboxylic acid (TCA) cycle is a housekeeping metabolic pathway essential
for generation of energy and biosynthetic intermediates. Alterations of the TCA cycle play …