It is more evident now than ever that nucleosomes can transmit epigenetic information from
one cell generation to the next. It has been demonstrated during the past decade that the …

The Saccharomyces cerevisiae Set1/COMPASS was the first histone H3 lysine 4 (H3K4)
methylase identified over 10 years ago. Since then, it has been demonstrated that Set1/…

More than 80 years ago, the first Polycomb-related phenotype was identified in Drosophila
melanogaster. Later, a group of diverse genes collectively called Polycomb group (PcG) …

Identification of protein–protein interactions often provides insight into protein function, and
many cellular processes are performed by stable protein complexes. We used tandem affinity …

A recent meeting (December 2008) regarding chromatin-based epigenetics was hosted by
the Banbury Conference Center and Cold Spring Harbor Laboratory. The intent was to …

Some patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
develop severe pneumonia and acute respiratory distress syndrome 1 (ARDS). Distinct …

Rationale: The contributions of diverse cell populations in the human lung to pulmonary
fibrosis pathogenesis are poorly understood. Single-cell RNA sequencing can reveal changes …

Set2 methylates Lys36 of histone H3. We show here that yeast Set2 copurifies with RNA
polymerase II (RNAPII). Chromatin immunoprecipitation analyses demonstrated that Set2 and …

Methylation of histone proteins is one of their many modifications that affect chromatin structure
and regulate gene expression. Methylation of histone H3 on lysines 4 and 79, catalyzed …

Little is known about the relative importance of monocyte and tissue-resident macrophages
in the development of lung fibrosis. We show that specific genetic deletion of monocyte-…