HIV is the top and tuberculosis is the second leading cause of death from infectious disease
worldwide, with an estimated 8.7 million incident cases of tuberculosis and 2.5 million new …

Tackling these challenges, using animal models, or careful prospective studies in humans
may prove to be worthwhile. There are already tantalizing examples where identification and …

Background An estimated 32,000 children develop multidrug-resistant tuberculosis (MDR-TB;
Mycobacterium tuberculosis resistant to isoniazid and rifampin) each year. Little is known …

The Complex Portal ( www.ebi.ac.uk/complexportal ) is a manually curated, encyclopaedic
database that collates and summarizes information on stable, macromolecular complexes of …

Background Two thirds of children with tuberculosis have nonsevere disease, which may be
treatable with a shorter regimen than the current 6-month regimen. Methods We conducted …

Importance The optimal dose and duration of oral amoxicillin for children with community-acquired
pneumonia (CAP) are unclear. Objective To determine whether lower-dose …

The 2015 Paediatric E uropean Network for Treatment of AIDS ( PENTA ) guidelines provide
practical recommendations on the management of HIV ‐1 infection in children in E urope …

Background Children with human immunodeficiency virus type 1 (HIV-1) infection have
limited options for effective antiretroviral treatment (ART). Methods We conducted an open-label, …

Prevention of mother-to-child transmission of hepatitis B virus (HBV) infection is a cornerstone
of efforts to support progress towards elimination of viral hepatitis. Current guidelines …

Background Paediatric dolutegravir doses approved by stringent regulatory authorities (SRAs)
for children weighing 20 kg to less than 40 kg until recently required 25 mg and 10 mg film…