Ordered mesoporous catalysts could open the door for new catalytic processes, based
partly on novel principles, owing to their hitherto unprecedented intrinsic features. For the …

The current guideline represents the 6th edition of the “Japanese Clinical Practice Guideline
for Diabetes” which has been revised every three years since its first appearance in 2004 to …

Bisphosphonates (BPs) have been widely, efficiently, and safely used for the treatment of
osteoporosis, malignant hypercalcemia, bone metastasis of solid cancers, and multiple …

The receptor for advanced glycation end products (RAGE), a multi-ligand member of the
immunoglobulin superfamily of cell surface molecules 1 , 2 , interacts with distinct molecules …

Recent studies suggested that interruption of the interaction of advanced glycation end products
(AGEs), with the signal-transducing receptor receptor for AGE (RAGE), by administration …

Advanced glycation end products (AGE) contribute to diabetic tissue injury by two major
mechanisms, ie, the alteration of extracellular matrix architecture through nonenzymatic glycation…

Recapitulating three-dimensional (3D) structures of complex organs, such as the kidney,
from pluripotent stem cells (PSCs) is a major challenge. Here, we define the developmental …

Aims Brugada syndrome is considered to be a distinctive subgroup of idiopathic ventricular
fibrillation. Identification of the circadian pattern of ventricular fibrillation would contribute to …

Reduced insulin-like signaling extends the life span of Caenorhabditis elegans and Drosophila.
Here, we show that, in mice, less insulin receptor substrate–2 (Irs2) signaling throughout …

INTRODUCTION The circadian clock is a molecular oscillator that coordinates behavior and
physiology in anticipation of the daily light cycle. Desynchrony of circadian cycles, through …