The intestine and skin are distinct microenvironments with unique physiological functions
and are continually exposed to diverse environmental challenges. Host adaptation at these …

OBJECTIVE: SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2)-related
pneumonia, referred to as COVID-19 (Coronavirus Disease 19), is a public health emergency …

Background Depression and anxiety have been associated with a range of symptoms that
often overlap. Depression, Anxiety and Stress Scale‐21 (DASS-21) is a single instrument to …

Background Standard treatment for patients with primary CNS lymphoma remains to be
defined. Active therapies are often associated with increased risk of haematological or …

Tissue repair is a subset of a broad repertoire of interleukin-4 (IL-4)– and IL-13–dependent
host responses during helminth infection. Here we show that IL-4 or IL-13 alone was not …

Non-lymphoid tissues (NLTs) harbor a pool of adaptive immune cells with largely unexplored
phenotype and development. We used single-cell RNA-seq to characterize 35,000 CD4 + …

In this randomized multicenter study of 136 patients, 6 courses of CHOP (cyclo-phosphamide/doxorubicin/vincristine/prednisone)
followed by rituximab (CHOP-R) were compared with …

A fundamental problem in rare-disease diagnostics is the lack of consensus as to which
genes have sufficient evidence to attribute causation. To address this issue, we have created …

Background The International Extranodal Lymphoma Study Group-32 (IELSG32) trial is an
international randomised phase 2 study that addresses two key clinical questions in the …

… Massimo Federico, Stefano Luminari, Alessandra Dondi, Alessandra Tucci, Umberto Vitolo,
Luigi Rigacci, Francesco Di Raimondo, Angelo Michele Carella, Alessandro Pulsoni …