We have tested the specificity and utility of more than 200 antibodies raised against 57 different
histone modifications in Drosophila melanogaster, Caenorhabditis elegans and human …

We systematically generated large-scale data sets to improve genome annotation for the
nematode Caenorhabditis elegans, a key model organism. These data sets include …

Genome function is dynamically regulated in part by chromatin, which consists of the histones,
non-histone proteins and RNA molecules that package DNA. Studies in Caenorhabditis …

Chromatin immunoprecipitation identifies specific interactions between genomic DNA and
proteins, advancing our understanding of gene-level and chromosome-level regulation. …

The cumulative knowledge of retina development has been instrumental in the generation of
retinal organoid systems from pluripotent stem cells; and these three-dimensional organoid …

Pre‐mRNA splicing is catalyzed by the spliceosome, a multimegadalton RNA–protein
complex. The spliceosome undergoes dramatic compositional and conformational changes …

Background Mutations in the GJB2 gene have been established as a major cause of inherited
non syndromic deafness in different populations. A high number of sequence variations …

The usherin gene (USH2A) has been screened for mutations causing Usher syndrome type
II (USH2). Two protein isoforms have been identified: a short isoform of 1,546 amino acids …

Background: Usher syndrome, a devastating recessive disorder which combines hearing
loss with retinitis pigmentosa, is clinically and genetically heterogeneous. Usher syndrome …

The Caenorhabditis elegans dosage compensation complex (DCC) equalizes X-chromosome
gene dosage between XO males and XX hermaphrodites by two-fold repression of X-…