User profiles for A. Vinuela
 | Ana ViñuelaNUAcT Fellow - Group leader Verified email at newcastle.ac.uk Cited by 7834 |
Underrepresented populations in Parkinson's genetics research: current landscape and future directions
…, S Urrehman, M Cornejo‐Olivas, A Vinuela… - Movement …, 2022 - Wiley Online Library
Background Human genetics research lacks diversity; over 80% of genome‐wide association
studies have been conducted on individuals of European ancestry. In addition to limiting …
studies have been conducted on individuals of European ancestry. In addition to limiting …
Cigarette smoking reduces DNA methylation levels at multiple genomic loci but the effect is partially reversible upon cessation
Smoking is a major risk factor in many diseases. Genome wide association studies have linked
genes for nicotine dependence and smoking behavior to increased risk of cardiovascular…
genes for nicotine dependence and smoking behavior to increased risk of cardiovascular…
Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans
Leukocyte telomere length (LTL) is associated with a number of common age-related diseases
and is a heritable trait. Previous genome-wide association studies (GWASs) identified …
and is a heritable trait. Previous genome-wide association studies (GWASs) identified …
Gene-gene and gene-environment interactions detected by transcriptome sequence analysis in twins
Understanding the genetic architecture of gene expression is an intermediate step in
understanding the genetic architecture of complex diseases. RNA sequencing technologies have …
understanding the genetic architecture of complex diseases. RNA sequencing technologies have …
[PDF][PDF] Population-scale tissue transcriptomics maps long non-coding RNAs to complex disease
Long non-coding RNA (lncRNA) genes have well-established and important impacts on
molecular and cellular functions. However, among the thousands of lncRNA genes, it is still a …
molecular and cellular functions. However, among the thousands of lncRNA genes, it is still a …
[PDF][PDF] Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study
The presentation and underlying pathophysiology of type 2 diabetes (T2D) is complex and
heterogeneous. Recent studies attempted to stratify T2D into distinct subgroups using data-…
heterogeneous. Recent studies attempted to stratify T2D into distinct subgroups using data-…
Tensor decomposition for multiple-tissue gene expression experiments
Genome-wide association studies of gene expression traits and other cellular phenotypes
have successfully identified links between genetic variation and biological processes. The …
have successfully identified links between genetic variation and biological processes. The …
[HTML][HTML] Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models
The application of multiple omics technologies in biomedical cohorts has the potential to reveal
patient-level disease characteristics and individualized response to treatment. However, …
patient-level disease characteristics and individualized response to treatment. However, …
Identification of seven loci affecting mean telomere length and their association with disease
Interindividual variation in mean leukocyte telomere length (LTL) is associated with cancer
and several age-associated diseases. We report here a genome-wide meta-analysis of …
and several age-associated diseases. We report here a genome-wide meta-analysis of …
[HTML][HTML] Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation
…, A Viñuela… - Nature …, 2015 - nature.com
Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease.
In 38,199 European ancestry individuals, we studied genome-wide association of forced …
In 38,199 European ancestry individuals, we studied genome-wide association of forced …