Therapy‐related myeloid neoplasms (t‐MNs) are serious long‐term consequences of cytotoxic
treatments for an antecedent disorder. t‐MNs are observed after ionizing radiation as well …

In recent years, melatonin, ie the major endocrine product of the pineal gland, was investigated
as to its possible regulatory role in the communication between the neuroendocrine and …

Acute myeloid leukemia (AML) is caused by malignant transformation of hematopoietic stem
or progenitor cells and displays the most frequent acute leukemia in adults. Although some …

Galactomannan detection in bronchoalveolar lavage (BAL) fluid samples (GM test) is
currently considered the gold standard test for diagnosing invasive pulmonary aspergillosis (IPA). …

Besides the pineal gland, melatonin is reported to be produced in a number of extrapineal
sites, where it could act as an intracellular mediator or paracrine signal in addition to its …

Deregulation of transcription factors (TFs) is an important driver of tumorigenesis, but non-invasive
assays for assessing transcription factor activity are lacking. Here we develop and …

Background In laboratory animals, exposure to most general anaesthetics leads to neurotoxicity
manifested by neuronal cell death and abnormal behaviour and cognition. Some large …

Background Therapy related myeloid neoplasms (t-MNs) are complex diseases originating
from an interplay between exogenous toxicities and a susceptible organism. It has been …

The antioxidant activity of melatonin (MEL) has been considered to constitute part of its
physiological as well as pharmacological effects. However, as described herein we found a …

This prospective, multicenter, epidemiological study was carried out in 99 Italian ICUs,
distributed throughout the country, from April 1993 to March 1994. In the study, we applied the …