[HTML][HTML] Characteristics of SARS-CoV-2 variants of concern B. 1.1. 7, B. 1.351 or P. 1: data from seven EU/EEA countries, weeks 38/2020 to 10/2021

…, A Vergison, AK Wienecke-Baldacchino… - …, 2021 - eurosurveillance.org
We compared 19,207 cases of SARS-CoV-2 variant B.1.1.7/S gene target failure (SGTF), 436
B.1.351 and 352 P.1 to non-variant cases reported by seven European countries. COVID-…

Gene-pair expression signatures reveal lineage control

…, M Nykter, R Kramer, A Wienecke-Baldacchino… - Nature …, 2013 - nature.com
The distinct cell types of multicellular organisms arise owing to constraints imposed by gene
regulatory networks on the collective change of gene expression across the genome, …

[HTML][HTML] Interferon-γ-induced activation of Signal Transducer and Activator of Transcription 1 (STAT1) up-regulates the tumor suppressing microRNA-29 family in …

…, C Margue, A Wienecke-Baldacchino… - Cell communication and …, 2012 - Springer
Background The type-II-cytokine IFN-γ is a pivotal player in innate immune responses but
also assumes functions in controlling tumor cell growth by orchestrating cellular responses …

[HTML][HTML] Genome-wide landscape of liver X receptor chromatin binding and gene regulation in human macrophages

…, J Diwo, J Ryynänen, A Wienecke-Baldacchino… - BMC genomics, 2012 - Springer
Background The liver X receptors (LXRs) are oxysterol sensing nuclear receptors with multiple
effects on metabolism and immune cells. However, the complete genome-wide cistrome …

Dataset integration identifies transcriptional regulation of microRNA genes by PPARγ in differentiating mouse 3T3-L1 adipocytes

E John, A Wienecke-Baldacchino… - Nucleic acids …, 2012 - academic.oup.com
Peroxisome proliferator-activated receptor γ (PPARγ) is a key transcription factor in mammalian
adipogenesis. Genome-wide approaches have identified thousands of PPARγ binding …

[HTML][HTML] Genome sequencing of SARS-CoV-2 allows monitoring of variants of concern through wastewater

…, P May, F Delogu, A Wienecke-Baldacchino… - Water, 2021 - mdpi.com
Monitoring SARS-CoV-2 in wastewater has shown to be an effective tool for epidemiological
surveillance. More specifically, RNA levels determined with RT-qPCR have been shown to …

[HTML][HTML] Deconvolution of transcriptomes and miRNomes by independent component analysis provides insights into biological processes and clinical outcomes of …

PV Nazarov, AK Wienecke-Baldacchino… - BMC medical …, 2019 - Springer
Background The amount of publicly available cancer-related “omics” data is constantly
growing and can potentially be used to gain insights into the tumour biology of new cancer …

[HTML][HTML] A new ALK isoform transported by extracellular vesicles confers drug resistance to melanoma cells

…, F Bernardin, G Van Niel, A Wienecke-Baldacchino… - Molecular cancer, 2018 - Springer
Background Drug resistance remains an unsolved clinical issue in oncology. Despite promising
initial responses obtained with BRAF and MEK kinase inhibitors, resistance to treatment …

[HTML][HTML] Case series of four re-infections with a SARS-CoV-2 B. 1.351 variant, Luxembourg, February 2021

…, T Abdelrahman, A Wienecke-Baldacchino… - …, 2021 - eurosurveillance.org
We describe four SARS-CoV-2 re-infections with a B.1.351 variant in 2021, in healthcare
workers (HCWs) previously infected in 2020, before detection of this variant in Europe. Cases …

The effects of sequence variation on genome-wide NRF2 binding—new target genes and regulatory SNPs

…, S Raju, A Wienecke-Baldacchino… - Nucleic acids …, 2016 - academic.oup.com
Transcription factor binding specificity is crucial for proper target gene regulation. Motif
discovery algorithms identify the main features of the binding patterns, but the accuracy on the …