With the quantity of genomic data increasing at an exponential rate, it is imperative that
these data be captured electronically, in a standard format. Standardization activities must …

Bacillus subtilis is the best-characterized member of the Gram-positive bacteria. Its genome
of 4,214,810 base pairs comprises 4,100 protein-coding genes. Of these protein-coding …

The re-use of previously validated designs is critical to the evolution of synthetic biology from
a research discipline to an engineering practice. Here we describe the Synthetic Biology …

To estimate the minimal gene set required to sustain bacterial life in nutritious conditions, we
carried out a systematic inactivation of Bacillus subtilis genes. Among ≈4,100 genes of the …

The international programme to sequence the 4.2 Mb genome of Bacillus subtilis, a model
Gram‐positive bacterium, is a joint project involving European, Japanese and US research …

Cellular senescence—the permanent arrest of cycling in normally proliferating cells such as
fibroblasts—contributes both to age‐related loss of mammalian tissue homeostasis and acts …

Motivation: In silico experiments in bioinformatics involve the co-ordinated use of computational
tools and information repositories. A growing number of these resources are being made …

ARIES is a population-based resource of DNA methylation data accessible by the research
community, established with the aim of improving our understanding of the determinants and …

Life sciences research is based on individuals, often with diverse skills, assembled into
research groups. These groups use their specialist expertise to address scientific problems. The …

As the Synthetic Biology Open Language (SBOL) data and visual standards gain acceptance
for describing genetic designs in a detailed and reproducible way, there is an increasing …