The Olig genes encode members of the basic helix-loop-helix (bHLH) family of transcription
factors. Olig1, Olig2, and Olig3 are expressed in both the developing and mature central …

Disclosures: Dr. Nolan reported personal fees from Angiocrine Bioscience during the conduct
of the study; in addition, Dr. Nolan had a patent number 9,944,897 issued" Angiocrine …

Regeneration of several organs involves adaptive reprogramming of progenitors, but the
intrinsic capacity of the developing brain to replenish lost cells remains largely unknown. Here …

During morphogenesis, molecular mechanisms that orchestrate biomechanical dynamics
across cells remain unclear. Here, we show a role of guidance receptor Plexin-B2 in …

The Olig genes encode members of the basic helix–loop–helix (bHLH) family of transcription
factors. Olig1, Olig2, and Olig3 are expressed in both the developing and mature central …

The main cell of origin of the Sonic hedgehog (SHH) subgroup of medulloblastoma (MB) is
granule cell precursors (GCPs), a SHH-dependent transient amplifying population in the …

The immune microenvironment of tumors can play a critical role in promoting or inhibiting
tumor progression depending on the context. We present evidence that tumor-associated …

For neural systems to function effectively, the numbers of each cell type must be proportioned
properly during development. We found that conditional knockout of the mouse homeobox …

Sulfs are secreted sulfatases that catalyse removal of sulfate from Heparan Sulfate
Proteoglycans (HSPGs) in the extracellular space. These enzymes are well known to regulate a …

Glioblastoma (GBM) is the most common primary malignant cancer of the central nervous
system. Insufficient oxygenation (hypoxia) has been linked to GBM invasion and aggression, …