Accumulating evidences indicate that many tumors rely on subpopulations of cancer stem
cells (CSCs) with the ability to propagate malignant clones indefinitely and to produce an overt …

The serine/threonine kinase human Pim1 (hereafter PIM1) cooperates with human c-Myc (hereafter
MYC) in cell cycle progression and tumorigenesis. However, the nature of this …

Pluripotent stem cells (PSCs) are defined by their self-renewal potential, which permits their
unlimited propagation, and their pluripotency, being able to generate cell of the three …

The phosphorylation of the serine 10 at histone H3 has been shown to be important for
transcriptional activation. Here, we report the molecular mechanism through which H3S10ph …

Simple Summary Although research on cancer biology in recent decades has unveiled the
main genetic perturbations driving the onset of tumorigenesis, we are still far from properly …

Mutations in one SETD5 allele are genetic causes of intellectual disability and autistic spectrum
disorders. However, the mechanisms by which SETD5 regulates brain development and …

The genetic elements required to tune gene expression are partitioned in active and repressive
nuclear condensates. Chromatin compartments include transcriptional clusters whose …

The tyrosine kinase receptor fetal liver kinase 1 (Flk-1) plays a crucial role in vasculogenesis
and angiogenesis, but its target genes remain elusive. Comparing Flk-1 +/+ with Flk-1 -/- …

Myc family members are critical to maintain embryonic stem cells (ESC) in the undifferentiated
state. However, the mechanism by which they perform this task has not yet been …

Breast cancer consists of highly heterogeneous tumors, whose cell of origin and driver
oncogenes are difficult to be uniquely defined. Here we report that MYC acts as tumor …