User profiles for A. des Georges
 | Amédée des GeorgesNYU Department of Molecular Pathobiology Verified email at gc.cuny.edu Cited by 3074 |
Ryanodine receptor structure and function in health and disease
Ryanodine receptors (RyRs) are ubiquitous intracellular calcium (Ca 2+ ) release channels
required for the function of many organs including heart and skeletal muscle, synaptic …
required for the function of many organs including heart and skeletal muscle, synaptic …
[PDF][PDF] Structural basis for gating and activation of RyR1
The type-1 ryanodine receptor (RyR1) is an intracellular calcium (Ca 2+ ) release channel
required for skeletal muscle contraction. Here, we present cryo-EM reconstructions of RyR1 in …
required for skeletal muscle contraction. Here, we present cryo-EM reconstructions of RyR1 in …
Routine single particle CryoEM sample and grid characterization by tomography
…, L Shapiro, PD Kwong, D Jeruzalmi, A Des Georges… - Elife, 2018 - elifesciences.org
10.7554/eLife.34257.001 Single particle cryo-electron microscopy (cryoEM) is often performed
under the assumption that particles are not adsorbed to the air-water interfaces and in thin…
under the assumption that particles are not adsorbed to the air-water interfaces and in thin…
[HTML][HTML] Structure of the mammalian ribosomal 43S preinitiation complex bound to the scanning factor DHX29
Eukaryotic translation initiation begins with assembly of a 43S preinitiation complex. First,
methionylated initiator methionine transfer RNA (Met-tRNA i Met ), eukaryotic initiation factor (…
methionylated initiator methionine transfer RNA (Met-tRNA i Met ), eukaryotic initiation factor (…
Structure of a mammalian ryanodine receptor
Ryanodine receptors (RyRs) mediate the rapid release of calcium (Ca 2+ ) from intracellular
stores into the cytosol, which is essential for numerous cellular functions including excitation…
stores into the cytosol, which is essential for numerous cellular functions including excitation…
Hepatitis-C-virus-like internal ribosome entry sites displace eIF3 to gain access to the 40S subunit
Hepatitis C virus (HCV) and classical swine fever virus (CSFV) messenger RNAs contain
related (HCV-like) internal ribosome entry sites (IRESs) that promote 5′-end independent …
related (HCV-like) internal ribosome entry sites (IRESs) that promote 5′-end independent …
Structure of an endosomal signaling GPCR–G protein–β-arrestin megacomplex
Classically, G-protein-coupled receptors (GPCRs) are thought to activate G protein from the
plasma membrane and are subsequently desensitized by β-arrestin (β-arr). However, some …
plasma membrane and are subsequently desensitized by β-arrestin (β-arr). However, some …
Structure of mammalian eIF3 in the context of the 43S preinitiation complex
A Des Georges, V Dhote, L Kuhn, CUT Hellen… - Nature, 2015 - nature.com
During eukaryotic translation initiation, 43S complexes, comprising a 40S ribosomal subunit,
initiator transfer RNA and initiation factors (eIF) 2, 3, 1 and 1A, attach to the 5′-terminal …
initiator transfer RNA and initiation factors (eIF) 2, 3, 1 and 1A, attach to the 5′-terminal …
High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome
Y Hashem, A Des Georges, J Fu, SN Buss, F Jossinet… - Nature, 2013 - nature.com
Ribosomes, the protein factories of living cells, translate genetic information carried by
messenger RNAs into proteins, and are thus involved in virtually all aspects of cellular …
messenger RNAs into proteins, and are thus involved in virtually all aspects of cellular …
Intermediates in SARS-CoV-2 spike–mediated cell entry
…, G McGill, T Gallagher, M Porotto, A Des Georges… - Science …, 2022 - science.org
SARS-CoV-2 cell entry is completed after viral spike (S) protein–mediated membrane fusion
between viral and host cell membranes. Stable prefusion and postfusion S structures have …
between viral and host cell membranes. Stable prefusion and postfusion S structures have …