Neurotransmitters, including catecholamines and serotonin, play a crucial role in maintaining
homeostasis in the human body. Studies on these neurotransmitters mainly revolved …

Purpose To investigate the impact of modern postoperative radiotherapy (PORT) on overall
survival (OS) for patients with N2 non–small-cell lung cancer (NSCLC) treated nationally …

Matrix metalloproteinases (MMPs) are a diverse group of proteolytic enzymes and play an
important role in the degradation and remodeling of the extracellular matrix (ECM). In normal …

Human cancers are complex ecosystems composed of cells with distinct phenotypes, genotypes,
and epigenetic states, but current models do not adequately reflect tumor composition …

… Finally, our definition of a p-EMT program helps relate a large body of EMT data to the in
vivo biology of a human tumor. Although further studies are needed, the association of this p-…

Background Neurological disorders are increasingly recognised as major causes of death
and disability worldwide. The aim of this analysis from the Global Burden of Diseases, Injuries…

… We classified cells into malignant and non-malignant cell types by combining three approaches
(Figures 1A, 1B, and S1C; STAR Methods). First, we inferred CNAs on the basis of the …

Although human tumours are shaped by the genetic evolution of cancer cells, evidence also
suggests that they display hierarchies related to developmental pathways and epigenetic …

Developmental fate decisions are dictated by master transcription factors (TFs) that interact
with cis-regulatory elements to direct transcriptional programs. Certain malignant tumors may …

… To assign a P value, we shuffled the assignments of cells to tumor types 10,000 times and
counted the fraction of times where an equal or larger difference is obtained for subsets of …