Evolutionary modification has produced a spectrum of animal defence traits to escape predation,
including the ability to autotomize body parts to elude capture 1 , 2 . After autotomy, the …

While considerable progress has been made towards understanding the complex processes
and pathways that regulate human wound healing, regenerative medicine has been …

Adult mammalian skin wounds heal by forming fibrotic scars. We report that full-thickness
injuries of reindeer antler skin (velvet) regenerate, whereas back skin forms fibrotic scar. Single-…

10.7554/eLife.24623.001 How the immune system affects tissue regeneration is not well
understood. In this study, we used an emerging mammalian model of epimorphic regeneration, …

Aging is often perceived as a degenerative process resulting from random accrual of cellular
damage over time. Despite this, age can be accurately estimated by epigenetic clocks …

Why mammals have poor regenerative ability has remained a long-standing question in
biology. In regenerating vertebrates, injury can induce a process known as epimorphic …

Congenital malformations of anorectal and genitourinary (collectively, anogenital) organs
occur at a high frequency in humans, however the lineage of cells that gives rise to anogenital …

Studying regeneration in animals where and when it occurs is inherently interesting and a
challenging research topic within developmental biology. Historically, vertebrate regeneration …

Aging, often considered a result of random cellular damage, can be accurately estimated
using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we …

Malformations of the external genitalia are among the most common congenital anomalies in
humans. The urogenital and anorectal sinuses develop from the embryonic cloaca, and the …