User profiles for AC Doxey
 | Andrew DoxeyAssociate Professor, University of Waterloo Verified email at uwaterloo.ca Cited by 3431 |
Unraveling the zoonotic origin and transmission of SARS-CoV-2
The origin and zoonotic transmission route of SARS-CoV-2 remain speculative. We discuss
scenarios for the zoonotic emergence of SARS-CoV-2, and also explore the missing …
scenarios for the zoonotic emergence of SARS-CoV-2, and also explore the missing …
Gene expression and in situ protein profiling of candidate SARS-CoV-2 receptors in human airway epithelial cells and lung tissue
… Conflict of interest: AC Doxey has nothing to disclose. … AC Doxey is supported by
NSERC and an Ontario Early Researcher Award. Funding information for this article has been …
NSERC and an Ontario Early Researcher Award. Funding information for this article has been …
[PDF][PDF] Metabolic flexibility determines human NK cell functional fate in the tumor microenvironment
NK cells are central to anti-tumor immunity and recently showed efficacy for treating
hematologic malignancies. However, their dysfunction in the hostile tumor microenvironment …
hematologic malignancies. However, their dysfunction in the hostile tumor microenvironment …
Discovery of novel bacterial toxins by genomics and computational biology
Hundreds and hundreds of bacterial protein toxins are presently known. Traditionally, toxin
identification begins with pathological studies of bacterial infectious disease. Following …
identification begins with pathological studies of bacterial infectious disease. Following …
AnnoTree: visualization and exploration of a functionally annotated microbial tree of life
Bacterial genomics has revolutionized our understanding of the microbial tree of life; however,
mapping and visualizing the distribution of functional traits across bacteria remains a …
mapping and visualizing the distribution of functional traits across bacteria remains a …
Functional Divergence in the Arabidopsis β-1,3-Glucanase Gene Family Inferred by Phylogenetic Reconstruction of Expression States
Plant β-1,3-glucanases (β-1,3-Gs) (EC 3.2.1.39) comprise large, highly complex gene families
involved in pathogen defense as well as a wide range of normal developmental processes…
involved in pathogen defense as well as a wide range of normal developmental processes…
Aquatic metagenomes implicate Thaumarchaeota in global cobalamin production
Cobalamin (vitamin B 12 ) is a complex metabolite and essential cofactor required by many
branches of life, including most eukaryotic phytoplankton. Algae and other cobalamin …
branches of life, including most eukaryotic phytoplankton. Algae and other cobalamin …
[PDF][PDF] Identification of a Botulinum Neurotoxin-like Toxin in a Commensal Strain of Enterococcus faecium
…, P Stenmark, MS Gilmore, AC Doxey… - Cell host & …, 2018 - cell.com
Botulinum neurotoxins (BoNTs), produced by various Clostridium strains, are a family of
potent bacterial toxins and potential bioterrorism agents. Here we report that an Enterococcus …
potent bacterial toxins and potential bioterrorism agents. Here we report that an Enterococcus …
Novel function discovery through sequence and structural data mining
… For example, Doxey and McConkey [52] predicted widespread mimicry of human extracellular
matrix proteins across a diverse range of human pathogenic bacteria based on detected …
matrix proteins across a diverse range of human pathogenic bacteria based on detected …
High functional diversity among Nitrospira populations that dominate rotating biological contactor microbial communities in a municipal wastewater treatment plant
Nitrification, the oxidation of ammonia to nitrate via nitrite, is an important process in municipal
wastewater treatment plants (WWTPs). Members of the Nitrospira genus that contribute to …
wastewater treatment plants (WWTPs). Members of the Nitrospira genus that contribute to …