Current therapies for medulloblastoma, a highly malignant childhood brain tumour, impose
debilitating effects on the developing child, and highlight the need for molecularly targeted …

Neurovascular coupling reflects the close temporal and regional linkage between neural
activity and cerebral blood flow. Although providing mechanistic insight, our understanding of …

Nucleophosmin (NPM1) is an abundant, oligomeric protein in the granular component of
the nucleolus with roles in ribosome biogenesis. Pentameric NPM1 undergoes liquid–liquid …

Cardiovascular issues following spinal cord injury (SCI) are of paramount importance
considering they are the leading cause of death in this population. The disruption of autonomic …

Cardiovascular (CV) issues after spinal cord injury (SCI) are of paramount importance
considering they are the leading cause of death in this population. Disruption of autonomic …

Spinal cord injury (SCI) induces haemodynamic instability that threatens survival 1 , 2 – 3 ,
impairs neurological recovery 4 , 5 , increases the risk of cardiovascular disease 6 , 7 , and …

Objective— Childhood obesity is associated with risk factors for cardiovascular disease.
Arterial stiffness is considered one of the earliest detectable measures of vascular damage. …

We combine molecular dynamics simulations and new high-field NMR experiments to
describe the solution structure of the Aβ 21–30 peptide fragment that may be relevant for …

Using homonuclear 1 H NOESY spectra, with chemical shifts, 3 J H N H α scalar couplings,
residual dipolar couplings, and 1 H- 15 N NOEs, we have optimized and validated the …

The interplay of modern molecular simulation and high-quality nuclear magnetic resonance
(NMR) experiments has reached a fruitful stage for quantitative characterization of structural …