User profiles for Aaron D. Gitler
 | Aaron D. GitlerProfessor of Genetics, Stanford University Verified email at stanford.edu Cited by 27683 |
α-Synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models
Alpha-synuclein (αSyn) misfolding is associated with several devastating neurodegenerative
disorders, including Parkinson's disease (PD). In yeast cells and in neurons αSyn …
disorders, including Parkinson's disease (PD). In yeast cells and in neurons αSyn …
Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS
Algorithms designed to identify canonical yeast prions predict that around 250 human
proteins, including several RNA-binding proteins associated with neurodegenerative disease, …
proteins, including several RNA-binding proteins associated with neurodegenerative disease, …
Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS
…, D Clay-Falcone, L McCluskey, L Elman, D Juhr… - Nature, 2010 - nature.com
The causes of amyotrophic lateral sclerosis (ALS), a devastating human neurodegenerative
disease, are poorly understood, although the protein TDP-43 has been suggested to have a …
disease, are poorly understood, although the protein TDP-43 has been suggested to have a …
Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways
Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease with no effective
treatment. We report the results of a moderate-scale sequencing study aimed at increasing the …
treatment. We report the results of a moderate-scale sequencing study aimed at increasing the …
Neurotoxic reactive astrocytes induce cell death via saturated lipids
Astrocytes regulate the response of the central nervous system to disease and injury and
have been hypothesized to actively kill neurons in neurodegenerative disease 1 , 2 , 3 , 4 , 5 – …
have been hypothesized to actively kill neurons in neurodegenerative disease 1 , 2 , 3 , 4 , 5 – …
Stress granules as crucibles of ALS pathogenesis
Amyotrophic lateral sclerosis (ALS) is a fatal human neurodegenerative disease affecting
primarily motor neurons. Two RNA-binding proteins, TDP-43 and FUS, aggregate in the …
primarily motor neurons. Two RNA-binding proteins, TDP-43 and FUS, aggregate in the …
[HTML][HTML] TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity
Non-amyloid, ubiquitinated cytoplasmic inclusions containing TDP-43 and its C-terminal
fragments are pathological hallmarks of amyotrophic lateral sclerosis (ALS), a fatal motor …
fragments are pathological hallmarks of amyotrophic lateral sclerosis (ALS), a fatal motor …
The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease
Prions are self-templating protein conformers that are naturally transmitted between individuals
and promote phenotypic change. In yeast, prion-encoded phenotypes can be beneficial, …
and promote phenotypic change. In yeast, prion-encoded phenotypes can be beneficial, …
[HTML][HTML] Neurodegenerative disease: models, mechanisms, and a new hope
Neurodegeneration is a feature of many debilitating, incurable diseases that are rapidly rising
in prevalence, such as Parkinson's disease. There is an urgent need to develop new and …
in prevalence, such as Parkinson's disease. There is an urgent need to develop new and …
[HTML][HTML] TDP-43 represses cryptic exon inclusion in the FTD–ALS gene UNC13A
A hallmark pathological feature of the neurodegenerative diseases amyotrophic lateral
sclerosis (ALS) and frontotemporal dementia (FTD) is the depletion of RNA-binding protein TDP-…
sclerosis (ALS) and frontotemporal dementia (FTD) is the depletion of RNA-binding protein TDP-…