Tissue and cell-type identity lie at the core of human physiology and disease. Understanding
the genetic underpinnings of complex tissues and individual cell lineages is crucial for …

Key challenges for human genetics, precision medicine and evolutionary biology include
deciphering the regulatory code of gene expression and understanding the transcriptional …

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with a strong
genetic basis. Yet, only a small fraction of potentially causal genes—about 65 genes out of an …

The size, shape, and behavior of the modern domesticated dog has been sculpted by artificial
selection for at least 14,000 years. The genetic substrates of selective breeding, however, …

Epigenomic profiling has enabled large-scale identification of regulatory elements, yet we
still lack a systematic mapping from any sequence or variant to regulatory activities. We …

We address the challenge of detecting the contribution of noncoding mutations to disease
with a deep-learning-based framework that predicts the specific regulatory effects and the …

A mutation in the canine multidrug resistance gene, MDR1, has previously been associated
with drug sensitivities in two breeds from the collie lineage. We exploited breed phylogeny …

Plant-based biomanufacturing of therapeutic proteins is a relatively new platform with a small
number of commercial-scale facilities, but offers advantages of linear scalability, reduced …

Interpreting the effects of genetic variants is key to understanding individual susceptibility to
disease and designing personalized therapeutic approaches. Modern experimental …

We present SEEK (search-based exploration of expression compendia; http://seek.princeton.edu/
), a query-based search engine for very large transcriptomic data collections, including …