Here we conducted a large-scale genetic association analysis of educational attainment in
a sample of approximately 1.1 million individuals and identify 1,271 independent genome-…

Osteoporosis is a common aging-related disease diagnosed primarily using bone mineral
density (BMD). We assessed genetic determinants of BMD as estimated by heel quantitative …

Humans vary substantially in their willingness to take risks. In a combined sample of over 1
million individuals, we conducted genome-wide association studies (GWAS) of general risk …

The extent to which low‐frequency (minor allele frequency (MAF) between 1–5%) and rare (MAF
≤ 1%) variants contribute to complex traits and disease in the general population is …

In human populations, assortative mating is almost universally positive, with similarities
between partners for quantitative phenotypes 1 – 6 , common disease risk 1 , 3 , 7 – 10 , …

Polygenic indexes (PGIs) are DNA-based predictors. Their value for research in many
scientific disciplines is growing rapidly. As a resource for researchers, we used a consistent …

Background Restless legs syndrome is a prevalent chronic neurological disorder with
potentially severe mental and physical health consequences. Clearer understanding of the …

Background Attention-deficit/hyperactivity disorder (ADHD) shows substantial heritability
and is two to seven times more common in male individuals than in female individuals. We …

Myeloproliferative neoplasms (MPNs) are blood cancers that are characterized by the
excessive production of mature myeloid cells and arise from the acquisition of somatic driver …

We conduct a large-scale genetic association analysis of educational attainment in a sample
of~ 1.1 million individuals and identify 1,271 independent genome-wide-significant SNPs. …