Reactive oxygen species (ROS) have emerged as important cellular-signaling agents for
cellular survival. Herein, we demonstrate that ROS-mediated oxidation of DNA to yield 8-oxo-7,…

The breadth and importance of RNA modifications are growing rapidly as modified
ribonucleotides can impact the sequence, structure, function, stability, and fate of RNAs and their …

G-quadruplex is a four-stranded G-rich DNA structure that is highly susceptible to oxidation.
Despite the important roles that G-quadruplexes play in telomere biology and gene …

Telomere shortening occurs during oxidative and inflammatory stress with guanine (G) as
the major site of damage. In this work, a comprehensive profile of the sites of oxidation and …

Oxidative damage to the genome can yield the base 8-oxo-7,8-dihydroguanine (OG). In
vitro studies suggested OG would preferentially form in 5′-GG-3′ sequence contexts after …

A high flux of reactive oxygen species during oxidative stress results in oxidative modification
of cellular components including DNA. Oxidative DNA “damage” to the heterocyclic bases …

Uncontrolled inflammation or oxidative stress generates electron-deficient species that
oxidize the genome increasing its instability in cancer. The G-quadruplex (G4) sequences …

Zika virus has emerged as a global concern because neither a vaccine nor antiviral
compounds targeting it exist. A structure for the positive-sense RNA genome has not been …

The telomeric DNA of vertebrates consists of d(TTAGGG) n tandem repeats, which can form
quadruplex DNA structures in vitro and likely in vivo. Despite the fact that the G-rich telomeric …

Living in an oxygen atmosphere demands an ability to thrive in the presence of reactive
oxygen species (ROS). Aerobic organisms have successfully found solutions to the oxidative …