CIViC is an expert-crowdsourced knowledgebase for Clinical Interpretation of Variants in
Cancer describing the therapeutic, prognostic, diagnostic and predisposing relevance of …

Identification of neoantigens is a critical step in predicting response to checkpoint blockade
therapy and design of personalized cancer vaccines. This is a cross-disciplinary challenge, …

CIViC is an expert crowdsourced knowledgebase for Clinical Interpretation of Variants in
Cancer ( www.civicdb.org ) describing the therapeutic, prognostic, and diagnostic relevance of …

Post-sequencing quality control is a crucial component of RNA sequencing (RNA-seq) data
generation and analysis, as sample quality can be affected by sample storage, extraction …

Determining protein levels in each tissue and how they compare with RNA levels is important
for understanding human biology and disease as well as regulatory processes that control …

Long non-coding RNA (lncRNA) genes have well-established and important impacts on
molecular and cellular functions. However, among the thousands of lncRNA genes, it is still a …

Background: Allogeneic hematopoietic cell transplantation (alloHCT) is the only curative
treatment for patients with myelodysplastic syndromes (MDS). Up to 40% of MDS patients will …

… 7 , Timothy James J Ley MD 8 , Timothy Aaron Graubert MD 9 , Matthew J. Walter MD 10 … ,
MDPhD,7 Timothy James J Ley, MD,8 Timothy Aaron Graubert, MD,9 Matthew J. Walter, MD10 …

More than 90% of drugs with preclinical activity fail in human trials, largely due to insufficient
efficacy. We hypothesized that adequately powered trials of patient-derived xenografts (PDX…

The application of modern high-throughput genomics to the study of cancer genomes has
exploded in the past few years, yielding unanticipated insights into the myriad and complex …