The spindle and kinetochore–associated (Ska) protein complex is a heterotrimeric complex
required for timely anaphase onset. The major phenotypes seen after small interfering RNA–…

MPS1 kinase is an essential component of the spindle assembly checkpoint (SAC), but its
functioning mechanisms are not fully understood. We have shown recently that direct …

OTSSP167 was recently characterized as a potent inhibitor for maternal embryonic leucine
zipper kinase (MELK) and is currently tested in Phase I clinical trials for solid tumors that …

Background Proteins functioning in the same biological pathway tend to be transcriptionally
co-regulated or form protein-protein interactions (PPI). Multiple spatially and temporally …

The mitotic checkpoint maintains genomic stability by ensuring that chromosomes are
accurately segregated during mitosis. When the checkpoint is activated, the mitotic checkpoint …

The microtubules of the mitotic spindle mediate chromosome alignment to the metaphase
plate, then sister chromatid segregation to the spindle poles in anaphase. Previous analyses …

In mitosis, the dynamic assembly and disassembly of microtubules are critical for normal
chromosome movement and segregation. Microtubule turnover varies among different mitotic …

The mitotic checkpoint is a specialized signal transduction pathway that monitors
kinetochore-microtubule attachment to achieve faithful chromosome segregation. MAD2 is an …

Forced expression of the cytokine-induced large GTPase, human Guanylate-Binding Protein-1
(hGBP-1), in ovarian cancer cell lines increases resistance to paclitaxel. Elevated hGBP-…

Ovarian cancer is the gynecological cancer with the poorest prognosis. One significant reason
is the development of resistance to the chemotherapeutic drugs used in its treatment. The …