User profiles for Aaron S. Brewster

Aaron S Brewster

Lawrence Berkeley National Labs
Verified email at lbl.gov
Cited by 6832

[HTML][HTML] DIALS: implementation and evaluation of a new integration package

…, DG Waterman, JM Parkhurst, AS Brewster… - … Section D: Structural …, 2018 - scripts.iucr.org
The DIALS project is a collaboration between Diamond Light Source, Lawrence Berkeley
National Laboratory and CCP4 to develop a new software suite for the analysis of …

Structure of the toxic core of α-synuclein from invisible crystals

…, AS Brewster, M Messerschmidt, S Boutet… - Nature, 2015 - nature.com
The protein α-synuclein is the main component of Lewy bodies, the neuron-associated
aggregates seen in Parkinson disease and other neurodegenerative pathologies. An 11-residue …

Structures of the intermediates of Kok's photosynthetic water oxidation clock

…, L Lassalle, M Ibrahim, S Gul, T Fransson, AS Brewster… - Nature, 2018 - nature.com
Inspired by the period-four oscillation in flash-induced oxygen evolution of photosystem II
discovered by Joliot in 1969, Kok performed additional experiments and proposed a five-state …

Structure of photosystem II and substrate binding at room temperature

…, S Gul, FD Fuller, S Koroidov, AS Brewster… - Nature, 2016 - nature.com
Light-induced oxidation of water by photosystem II (PS II) in plants, algae and cyanobacteria
has generated most of the dioxygen in the atmosphere. PS II, a membrane-bound multi-…

Architecture of the synaptotagmin–SNARE machinery for neuronal exocytosis

…, M Uervirojnangkoorn, OB Zeldin, AS Brewster… - Nature, 2015 - nature.com
Synaptotagmin-1 and neuronal SNARE proteins have central roles in evoked synchronous
neurotransmitter release; however, it is unknown how they cooperate to trigger synaptic …

[HTML][HTML] Structural evidence for intermediates during O2 formation in photosystem II

…, NW Moriarty, F Mamedov, PD Adams, AS Brewster… - Nature, 2023 - nature.com
In natural photosynthesis, the light-driven splitting of water into electrons, protons and
molecular oxygen forms the first step of the solar-to-chemical energy conversion process. The …

[HTML][HTML] Taking snapshots of photosynthetic water oxidation using femtosecond X-ray diffraction and spectroscopy

…, B Lassalle-Kaiser, R Chatterjee, AS Brewster… - Nature …, 2014 - nature.com
The dioxygen we breathe is formed by light-induced oxidation of water in photosystem II. O
2 formation takes place at a catalytic manganese cluster within milliseconds after the …

Drop-on-demand sample delivery for studying biocatalysts in action at X-ray free-electron lasers

…, ID Young, H Lebrette, V Srinivas, AS Brewster… - Nature …, 2017 - nature.com
X-ray crystallography at X-ray free-electron laser sources is a powerful method for studying
macromolecules at biologically relevant temperatures. Moreover, when combined with …

[HTML][HTML] Diffraction-geometry refinement in the DIALS framework

…, RJ Gildea, JM Parkhurst, AS Brewster… - … Section D: Structural …, 2016 - scripts.iucr.org
Rapid data collection and modern computing resources provide the opportunity to revisit the
task of optimizing the model of diffraction geometry prior to integration. A comprehensive …

Untangling the sequence of events during the S2S3 transition in photosystem II and implications for the water oxidation mechanism

…, JM Holton, H Dobbek, AS Brewster… - Proceedings of the …, 2020 - National Acad Sciences
In oxygenic photosynthesis, light-driven oxidation of water to molecular oxygen is carried out
by the oxygen-evolving complex (OEC) in photosystem II (PS II). Recently, we reported the …