Chemical modifications of histones can mediate diverse DNA-templated processes,
including gene transcription 1 , 2 – 3 . Here we provide evidence for a class of histone post-…

Glioblastoma (GBM), a highly lethal brain cancer, is notorious for immunosuppression, but
the mechanisms remain unclear. Here, we documented a temporospatial patterning of tumor-…

Vulnerability to relapse during periods of attempted abstinence from cocaine use is hypothesized
to result from the rewiring of brain reward circuitries, particularly ventral tegmental area …

Abuse, neglect, and other forms of early life stress (ELS) significantly increase risk for psychiatric
disorders including depression. In this study, we show that ELS in a postnatal sensitive …

Animals susceptible to chronic social defeat stress (CSDS) exhibit depression-related
behaviors, with aberrant transcription across several limbic brain regions, most notably in the …

Opioid use disorder (OUD) looms as one of the most severe medical crises facing society.
More effective therapeutics will require a deeper understanding of molecular changes …

Background Global changes in gene expression underlying circuit and behavioral dysregulation
associated with cocaine addiction remain incompletely understood. Here, we show how …

Cocaine use disorder (CUD) is an intractable syndrome, and rising overdose death rates
represent a substantial public health crisis that exacts tremendous personal and financial costs …

Major depressive disorder (MDD) is the leading cause of disability worldwide. There is an
urgent need for objective biomarkers to diagnose this highly heterogeneous syndrome, assign …

Depression is a common disorder that affects women at twice the rate of men. Here, we report
that long non-coding RNAs (lncRNAs), a recently discovered class of regulatory transcripts…