Binding of Plasmodium merozoite proteins RON2 and AMA1 triggers commitment to invasion
P Srinivasan, WL Beatty, A Diouf… - Proceedings of the …, 2011 - National Acad Sciences
The commitment of Plasmodium merozoites to invade red blood cells (RBCs) is marked by
the formation of a junction between the merozoite and the RBC and the coordinated induction …
the formation of a junction between the merozoite and the RBC and the coordinated induction …
[PDF][PDF] A PfRH5-based vaccine is efficacious against heterologous strain blood-stage Plasmodium falciparum infection in aotus monkeys
…, C Crosnier, SJ Bartholdson, A Diouf… - Cell host & …, 2015 - cell.com
Antigenic diversity has posed a critical barrier to vaccine development against the pathogenic
blood-stage infection of the human malaria parasite Plasmodium falciparum. To date, only …
blood-stage infection of the human malaria parasite Plasmodium falciparum. To date, only …
[PDF][PDF] Reduced blood-stage malaria growth and immune correlates in humans following RH5 vaccination
…, SE Silk, JR Barrett, CM Nielsen, K Miura, A Diouf… - Med, 2021 - cell.com
Background Development of an effective vaccine against the pathogenic blood-stage infection
of human malaria has proved challenging, and no candidate vaccine has affected blood-…
of human malaria has proved challenging, and no candidate vaccine has affected blood-…
Vaccination with Plasmodium vivax Duffy-binding protein inhibits parasite growth during controlled human malaria infection
…, Y Themistocleous, TA Rawlinson, A Diouf… - Science translational …, 2023 - science.org
There are no licensed vaccines against Plasmodium vivax. We conducted two phase 1/2a
clinical trials to assess two vaccines targeting P. vivax Duffy-binding protein region II (PvDBPII)…
clinical trials to assess two vaccines targeting P. vivax Duffy-binding protein region II (PvDBPII)…
Naturally Acquired Antibodies Specific for Plasmodium falciparum Reticulocyte-Binding Protein Homologue 5 Inhibit Parasite Growth and Predict Protection From …
…, J Coursen, C Crosnier, A Diouf… - The Journal of …, 2014 - academic.oup.com
Background. Plasmodium falciparum reticulocyte-binding protein homologue 5 (PfRH5) is a
blood-stage parasite protein essential for host erythrocyte invasion. PfRH5-specific …
blood-stage parasite protein essential for host erythrocyte invasion. PfRH5-specific …
[HTML][HTML] Human vaccination against RH5 induces neutralizing antimalarial antibodies that inhibit RH5 invasion complex interactions
RO Payne, SE Silk, SC Elias, K Miura, A Diouf… - JCI insight, 2017 - ncbi.nlm.nih.gov
The development of a highly effective vaccine remains a key strategic goal to aid the control
and eventual eradication of Plasmodium falciparum malaria. In recent years, the reticulocyte-…
and eventual eradication of Plasmodium falciparum malaria. In recent years, the reticulocyte-…
Functional comparison of Plasmodium falciparum transmission-blocking vaccine candidates by the standard membrane-feeding assay
…, E Takashima, B Deng, G Tullo, A Diouf… - Infection and …, 2013 - Am Soc Microbiol
Recently, there has been a renewed interest in the development of transmission-blocking
vaccines (TBV) against Plasmodium falciparum malaria. While several candidate TBVs have …
vaccines (TBV) against Plasmodium falciparum malaria. While several candidate TBVs have …
[HTML][HTML] Enhancing Blockade of Plasmodium falciparum Erythrocyte Invasion: Assessing Combinations of Antibodies against PfRH5 and Other Merozoite Antigens
…, P Choudhary, LM Murungi, JM Furze, A Diouf… - PLoS …, 2012 - journals.plos.org
No vaccine has yet proven effective against the blood-stages of Plasmodium falciparum, which
cause the symptoms and severe manifestations of malaria. We recently found that PfRH5, …
cause the symptoms and severe manifestations of malaria. We recently found that PfRH5, …
[HTML][HTML] Qualification of Standard Membrane-Feeding Assay with Plasmodium falciparum Malaria and Potential Improvements for Future Assays
K Miura, B Deng, G Tullo, A Diouf, SE Moretz, E Locke… - PloS one, 2013 - journals.plos.org
Vaccines that interrupt malaria transmission are of increasing interest and a robust functional
assay to measure this activity would promote their development by providing a biologically …
assay to measure this activity would promote their development by providing a biologically …
Immunization with a functional protein complex required for erythrocyte invasion protects against lethal malaria
P Srinivasan, E Ekanem, A Diouf… - Proceedings of the …, 2014 - National Acad Sciences
An essential step in the invasion of red blood cells (RBCs) by Plasmodium falciparum (Pf)
merozoites is the binding of rhoptry neck protein 2 (RON2) to the hydrophobic groove of apical …
merozoites is the binding of rhoptry neck protein 2 (RON2) to the hydrophobic groove of apical …