Production of reactive oxygen species (ROS) is a key instigator of β-cell dysfunction in
diabetes. The pleiotropic cytokine interleukin 6 (IL-6) has previously been linked to β-cell …

Methods Pancreases were collected from chloroquine-injected and non-injected non-obese
diabetes-resistant (NOR) and non-obese diabetic (NOD) mice. Age-and BMI-matched …

The pancreatic islet is a complex micro-organ containing numerous cell types, including
endocrine, immune, and endothelial cells. The communication of these systems is lost upon …

Islet β-cell dysfunction and aggressive macrophage activity are early features in the pathogenesis
of type 1 diabetes (T1D). 12/15-Lipoxygenase (12/15-LOX) is induced in β-cells and …

Coronary perivascular adipose tissue is a naturally occurring adipose tissue depot that
normally surrounds the major coronary arteries on the surface of the heart. Although originally …

Pancreatic ductal adenocarcinomas (PDACs) are aggressive with frequent lymphatic spread.
By analysis of data from The Cancer Genome Atlas, we determined that ~35% of PDACs …

It is well known that a chronic state of elevated reactive oxygen species (ROS) in pancreatic
β-cells impairs their ability to release insulin in response to elevated plasma glucose. …

In type 1 diabetes, an autoimmune event increases oxidative stress in islet β cells, giving
rise to cellular dysfunction and apoptosis. Lipoxygenases are enzymes that catalyze the …

This study tested the hypothesis that obesity alters the cardiac response to ischemia/reperfusion
and/or glucagon like peptide-1 (GLP-1) receptor activation, and that these differences …

This study tested the hypothesis that glucagon-like peptide 1 (GLP-1) therapies improve
cardiac contractile function at rest and in response to adrenergic stimulation in obese swine …