User profiles for Abbigail Helfer
 | Abbigail HelferDuke University Verified email at duke.edu Cited by 322 |
[PDF][PDF] Single-cell transcriptomic analysis of cardiac differentiation from human PSCs reveals HOPX-dependent cardiomyocyte maturation
Cardiac differentiation of human pluripotent stem cells (hPSCs) requires orchestration of
dynamic gene regulatory networks during stepwise fate transitions but often generates …
dynamic gene regulatory networks during stepwise fate transitions but often generates …
Biomaterializing the promise of cardiac tissue engineering
During an average individual's lifespan, the human heart pumps nearly 200 million liters of
blood delivered by approximately 3 billion heartbeats. Therefore, it is not surprising that …
blood delivered by approximately 3 billion heartbeats. Therefore, it is not surprising that …
Time-dependent effects of BRAF-V600E on cell cycling, metabolism, and function in engineered myocardium
Candidate cardiomyocyte (CM) mitogens such as those affecting the extracellular signal–regulated
kinase (ERK) signaling pathway represent potential targets for functional heart …
kinase (ERK) signaling pathway represent potential targets for functional heart …
Frame-hydrogel methodology for engineering highly functional cardiac tissue constructs
Engineered cardiac tissues hold tremendous promise for in vitro drug discovery, studies of
heart development and disease, and therapeutic applications. Here, we describe a versatile “…
heart development and disease, and therapeutic applications. Here, we describe a versatile “…
[PDF][PDF] Temporal perturbation of histone deacetylase activity reveals a requirement for HDAC1–3 in mesendoderm cell differentiation
Histone deacetylases (HDACs) are a class of enzymes that control chromatin state and
influence cell fate. We evaluated the chromatin accessibility and transcriptome dynamics of zinc-…
influence cell fate. We evaluated the chromatin accessibility and transcriptome dynamics of zinc-…
Analysis of cardiac differentiation at single cell resolution reveals a requirement of hypertrophic signaling for HOPX transcription
Differentiation into diverse cell lineages requires orchestration of gene regulatory networks
guiding cell fate choices. Here, we present the dissection of cellular composition and gene …
guiding cell fate choices. Here, we present the dissection of cellular composition and gene …
Cardiac Directed Differentiation Using Small Molecule WNT Modulation at Single-Cell Resolution
Differentiation into diverse cell lineages requires orchestration of gene regulatory networks
guiding cell fate choices. Here, we present the dissection of cellular composition and gene …
guiding cell fate choices. Here, we present the dissection of cellular composition and gene …
The D801N Variant in ATP1A3-Encoded Na/K-atpase Alpha 3 Shortens the Cardiac Myocyte Action Potential and Increases Risk for Calcium Mediated Arrhythmias
Background: Alternating hemiplegia of childhood (AHC) is a rare de novo syndrome that
manifests with episodic hemiplegia, seizures, dystonia, and, notably, sudden unexplained death…
manifests with episodic hemiplegia, seizures, dystonia, and, notably, sudden unexplained death…
[BOOK][B] Cardiac Regeneration
Myocardial infarction (MI) is a life-threatening injury causing permanent loss of cardiomyocytes.
MI events are experienced by over 750,000 people each year in the United States, with …
MI events are experienced by over 750,000 people each year in the United States, with …
The role of metabolism in cardiomyocyte maturation, disease and regeneration
JW Miklas - 2018 - digital.lib.washington.edu
Cardiovascular disease, broadly encompassing both genetic and environmental cardiac
pathology, remains the leading cause of death. As such, there is a great need to better model …
pathology, remains the leading cause of death. As such, there is a great need to better model …