Pierre Robin sequence (PRS) is an important subgroup of cleft palate. We report several lines
of evidence for the existence of a 17q24 locus underlying PRS, including linkage analysis …

The epicardial epithelial-mesenchymal transition (EMT) is hypothesized to generate
cardiovascular progenitor cells that differentiate into various cell types, including coronary smooth …

In this study, we have used the human BV173 and the mouse BaF3/Bcr-Abl-expressing cell
lines as model systems to investigate the molecular mechanisms whereby STI571 and …

Over half of all proteins are glycosylated, and alterations in glycosylation have been observed
in numerous physiological and pathological processes. Attached glycans significantly …

Wt1 regulates the epithelial-mesenchymal transition (EMT) in the epicardium and the
reverse process (MET) in kidney mesenchyme. The mechanisms underlying these reciprocal …

Sonic hedgehog (Shh) expression during limb development is crucial for specifying the identity
and number of digits. The spatial pattern of Shh expression is restricted to a region called …

Forkhead transcription factors of the O class (FOXOs) are important targets of the
phosphatidylinositol 3-kinase (PI3-kinase)/Akt pathway. FOXOs have been implicated in the …

Cell cycle arrest by FoxO transcription factors involves transcriptional repression of cyclin D,
although the exact mechanism remains unclear. In this study, we used the BCR-ABL-…

A recent genome-wide association study identified hepatocyte nuclear factor 1-α (HNF1A)
as a key regulator of fucosylation. We hypothesized that loss-of-function HNF1A mutations …

Menstruation, or cyclic shedding of nonpregnant endometrial tissue with associated bleeding,
occurs only in humans and a few other species. This breakdown of the endometrium in …