We have isolated artificial ligands or aptamers for infectious prions in order to investigate
conformational aspects of prion pathogenesis. The aptamers are 2′-fluoro-modified RNA …

New evidence indicates that termination of transcription is an important regulatory step,
closely related to transcriptional interference 1 and even transcriptional initiation 2 . However, …

Les auteurs ont isolé un clone ADNc, le Le-MI-13 (Lycopersicon esculentum, induit par la
mycorhize) par tamisage différentiel d'une librairie ADNc préparée à partir d'ARNm extrait de …

We have recently described the isolation of 2′-fluoropyrimidine-substituted RNA aptamers
that bind selectively to disease-associated β-sheet-rich forms of the prion protein, PrP, from a …

We have isolated 2′-Fluoro-substituted RNA aptamers that bind to streptavidin (SA) with
an affinity around 7 ± 1.8 nM, comparable with that of recently described peptide aptamers. …

Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) is a leading
asexual blood-stage vaccine candidate for malaria. In preparation for clinical trials, a full-length …

The conformational transition of the human prion protein from an α-helical to a β-sheet-rich
structure is believed to be the critical event in prion pathogenesis. The molecular mechanism …

The human PrP gene (PRNP) has two common alleles that encode either methionine or
valine at codon 129. This polymorphism modulates disease susceptibility and phenotype of …

The polymorphism at residue 129 of the human PRNP gene modulates disease
susceptibility and the clinico-pathological phenotypes in human transmissible spongiform …

Intermediate states are key to understanding the molecular mechanisms governing protein
misfolding. The human prion protein (PrP) can follow various misfolding pathways, and forms …