The impact of epigenetics on the differentiation of memory T (Tmem) cells is poorly defined.
We generated deep epigenomes comprising genome-wide profiles of DNA methylation, …

Background Partially methylated domains are extended regions in the genome exhibiting a
reduced average DNA methylation level. They cover gene-poor and transcriptionally inactive …

Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous
system with a modest concordance rate in monozygotic twins, which strongly argues for …

CD4+ regulatory T cells (Tregs) are key mediators of immunological tolerance and promising
effector cells for immuno-suppressive adoptive cellular therapy to fight autoimmunity and …

Chromatin accessibility maps are important for the functional interpretation of the genome.
Here, we systematically analysed assay specific differences between DNase I-seq, ATAC-seq …

Adoptive transfer of regulatory T cells (Treg) is a promising new therapeutic option to treat
detrimental inflammatory conditions after transplantation and during autoimmune disease. To …

Background & Aims Pluripotent stem cell (PSC)-derived hepatocyte-like cells (HLC) have
enormous potential as a replacement for primary hepatocytes in drug screening, toxicology …

Dimethyl sulfoxide (DMSO) is used to sustain or favor hepatocyte differentiation in vitro. Thus,
DMSO is used in the differentiation protocol of the HepaRG cells that present the closest …

Astrocytes from the cerebral cortex (CTX) and cerebellum (CB) share basic molecular programs,
but also form distinct spatial and functional subtypes. The regulatory epigenetic layers …

The unicellular ciliate Paramecium contains a large vegetative macronucleus with several
unusual characteristics, including an extremely high coding density and high polyploidy. As …