[HTML][HTML] Bromodomain and extraterminal protein inhibitor, apabetalone (RVX-208), reduces ACE2 expression and attenuates SARS-Cov-2 infection in vitro

D Gilham, AL Smith, L Fu, DY Moore, A Muralidharan… - Biomedicines, 2021 - mdpi.com
Effective therapeutics are urgently needed to counter infection and improve outcomes for
patients suffering from COVID-19 and to combat this pandemic. Manipulation of epigenetic …

Influenza infection induces alveolar macrophage dysfunction and thereby enables noninvasive Streptococcus pneumoniae to cause deadly pneumonia

…, S Bansal, C Bauer, A Muralidharan… - The Journal of …, 2020 - journals.aai.org
Secondary Streptococcus pneumoniae infection is a significant cause of morbidity and mortality
during influenza epidemics and pandemics. Multiple pathogenic mechanisms, such as …

[HTML][HTML] SARS-CoV-2 dysregulates neutrophil degranulation and reduces lymphocyte counts

A Muralidharan, TA Wyatt, SP Reid - Biomedicines, 2022 - mdpi.com
SARS-CoV-2, the virus that causes COVID-19, has given rise to one of the largest pandemics,
affecting millions worldwide. High neutrophil-to-lymphocyte ratios have been identified as …

Immunopathogenesis associated with formaldehyde-inactivated RSV vaccine in preclinical and clinical studies

A Muralidharan, C Li, L Wang, X Li - Expert review of vaccines, 2017 - Taylor & Francis
Introduction: Respiratory syncytial virus (RSV) infection is responsible for one-third of deaths
of acute lower respiratory infection in children less than one-year-old. The formaldehyde-…

Chitosan alters inactivated respiratory syncytial virus vaccine elicited immune responses without affecting lung histopathology in mice

A Muralidharan, MS Russell, L Larocque, C Gravel… - Vaccine, 2019 - Elsevier
Chitosan is a polysaccharide capable of augmenting immune responses with a proven safety
record in animals and humans. These properties make it a potentially attractive agent for …

Malondialdehyde acetaldehyde adduction of surfactant protein D attenuates SARS‐CoV‐2 spike protein binding and virus neutralization

A Muralidharan, C Bauer, DM Katafiasz… - Alcohol: Clinical and …, 2023 - Wiley Online Library
Background Over 43% of the world's population regularly consumes alcohol. Although not
commonly known, alcohol can have a significant impact on the respiratory environment. …

[HTML][HTML] Synergistic detrimental effects of cigarette smoke, alcohol, and SARS-CoV-2 in COPD bronchial epithelial cells

A Muralidharan, CD Bauer, DM Katafiasz, HM Strah… - Pathogens, 2023 - mdpi.com
Lung conditions such as COPD, as well as risk factors such as alcohol misuse and cigarette
smoking, can exacerbate COVID-19 disease severity. Synergistically, these risk factors can …

[HTML][HTML] Complex roles of neutrophils during arboviral infections

A Muralidharan, SP Reid - Cells, 2021 - mdpi.com
Arboviruses are known to cause large-scale epidemics in many parts of the world. These
arthropod-borne viruses are a large group consisting of viruses from a wide range of families. …

[HTML][HTML] IFN-γ attenuates eosinophilic inflammation but is not essential for protection against RSV-enhanced asthmatic comorbidity in adult mice

A Muralidharan, MB Uddin, C Bauer, W Wu, X Bao… - Viruses, 2022 - mdpi.com
The susceptibility to respiratory syncytial virus (RSV) infection in early life has been associated
with a deficient T-helper cell type 1 (Th1) response. Conversely, healthy adults generally …

[HTML][HTML] Targeting CD40 enhances antibody-and CD8-mediated protection against respiratory syncytial virus infection

A Muralidharan, M Russell, L Larocque, C Gravel… - Scientific Reports, 2018 - nature.com
Respiratory Syncytial Virus (RSV) infects almost all children under the age of one and is the
leading cause of hospitalization among infants. Despite several decades of research with …