Network medicine is an emerging area of research dealing with molecular and genetic
interactions, network biomarkers of disease, and therapeutic target discovery. Large-scale …

Although all human tissues carry out common processes, tissues are distinguished by gene
expression patterns, implying that distinct regulatory programs control tissue specificity. In …

Sex differences manifest in many diseases and may drive sex-specific therapeutic responses.
To understand the molecular basis of sex differences, we evaluated sex-biased gene …

Characterizing the collective regulatory impact of genetic variants on complex phenotypes
is a major challenge in developing a genotype to phenotype map. Using expression …

Cardiovascular diseases (CVD) are diverse disorders affecting the heart and vasculature in
millions of people worldwide. Like other fields, CVD research has benefitted from the deluge …

Aims Calcific aortic valve disease (CAVD) is the most common valve disease, which consists
of a chronic interplay of inflammation, fibrosis, and calcification. In this study, sortilin (SORT1…

Gene regulation plays a fundamental role in shaping tissue identity, function, and response
to perturbation. Regulatory processes are controlled by complex networks of interacting …

Inference and analysis of gene regulatory networks (GRNs) require software that integrates
multi-omic data from various sources. The Network Zoo (netZoo; netzoo.github.io) is a …

Background Peripheral arterial disease (PAD) is estimated to affect 7% of the adult population
in the United States; however, there is currently little understanding of the key cellular and …

Epigenetic mechanisms integrate both genetic variability and environmental exposures.
However, comprehensive epigenome-wide analysis has not been performed across major …