[PDF][PDF] Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein
The emergence of SARS-CoV-2 has resulted in >90,000 infections and >3,000 deaths.
Coronavirus spike (S) glycoproteins promote entry into cells and are the main target of antibodies…
Coronavirus spike (S) glycoproteins promote entry into cells and are the main target of antibodies…
[PDF][PDF] Immunization with a self-assembling nanoparticle vaccine displaying EBV gH/gL protects humanized mice against lethal viral challenge
…, AJ Borst, JY Wang, C Walkey, J Price, A Wall… - Cell Reports …, 2022 - cell.com
Epstein-Barr virus (EBV) is a cancer-associated pathogen responsible for 165,000 deaths
annually. EBV is also the etiological agent of infectious mononucleosis and is linked to …
annually. EBV is also the etiological agent of infectious mononucleosis and is linked to …
[PDF][PDF] Single-cell profiling of an in vitro model of human interneuron development reveals temporal dynamics of cell type production and maturation
GABAergic interneurons are essential for neural circuit function, and their loss or dysfunction
is implicated in human neuropsychiatric disease. In vitro methods for interneuron …
is implicated in human neuropsychiatric disease. In vitro methods for interneuron …
CD4 binding site immunogens elicit heterologous anti–HIV-1 neutralizing antibodies in transgenic and wild-type animals
…, TY Oliveira, Y Nishimura, NS Koranda, A Wall… - Science …, 2023 - science.org
Passive transfer of broadly neutralizing anti–HIV-1 antibodies (bNAbs) protects against
infection, and therefore, eliciting bNAbs by vaccination is a major goal of HIV-1 vaccine efforts. …
infection, and therefore, eliciting bNAbs by vaccination is a major goal of HIV-1 vaccine efforts. …
[PDF][PDF] Structures of drug-specific monoclonal antibodies bound to opioids and nicotine reveal a common mode of binding
Opioid-related fatal overdoses have reached epidemic proportions. Because existing treatments
for opioid use disorders offer limited long-term protection, accelerating the development …
for opioid use disorders offer limited long-term protection, accelerating the development …
[PDF][PDF] Development of a VRC01-class germline targeting immunogen derived from anti-idiotypic antibodies
E Seydoux, YH Wan, J Feng, A Wall, S Aljedani… - Cell reports, 2021 - cell.com
An effective HIV-1 vaccine will likely need to elicit broadly neutralizing antibodies (bNAbs).
Broad and potent VRC01-class bNAbs have been isolated from multiple infected individuals, …
Broad and potent VRC01-class bNAbs have been isolated from multiple infected individuals, …
Anti-idiotypic antibodies elicit anti-HIV-1–specific B cell responses
P Dosenovic, AK Pettersson, A Wall… - Journal of Experimental …, 2019 - rupress.org
Human anti-HIV-1 broadly neutralizing antibodies (bNAbs) protect against infection in
animal models. However, bNAbs have not been elicited by vaccination in diverse wild-type …
animal models. However, bNAbs have not been elicited by vaccination in diverse wild-type …
[HTML][HTML] Detection and activation of HIV broadly neutralizing antibody precursor B cells using anti-idiotypes
…, C Weidle, A Schwartz, A Wall… - Journal of Experimental …, 2019 - rupress.org
Many tested vaccines fail to provide protection against disease despite the induction of
antibodies that bind the pathogen of interest. In light of this, there is much interest in rationally …
antibodies that bind the pathogen of interest. In light of this, there is much interest in rationally …
Generation of a cost-effective cell line for support of high-throughput isolation of primary human B cells and monoclonal neutralizing antibodies
…, S Ameny, T Arkatkar, A Seese, A Wall… - Journal of …, 2021 - Elsevier
The isolation of human monoclonal antibodies (mAbs) arising from natural infection with
human pathogens has proven to be a powerful technology, facilitating the understanding of the …
human pathogens has proven to be a powerful technology, facilitating the understanding of the …
Structures of aspartate aminotransferases from Trypanosoma brucei, Leishmania major and Giardia lamblia
J Abendroth, R Choi, A Wall, MC Clifton… - … Section F: Structural …, 2015 - scripts.iucr.org
The structures of three aspartate aminotransferases (AATs) from eukaryotic pathogens were
solved within the Seattle Structural Genomics Center for Infectious Disease (SSGCID). Both …
solved within the Seattle Structural Genomics Center for Infectious Disease (SSGCID). Both …