Humans vary substantially in their willingness to take risks. In a combined sample of over 1
million individuals, we conducted genome-wide association studies (GWAS) of general risk …

Liability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic
architecture or its genetic relationship with other disorders. To discover loci associated …

Behaviors and disorders related to self-regulation, such as substance use, antisocial behavior
and attention-deficit/hyperactivity disorder, are collectively referred to as externalizing and …

The JAX Diversity Outbred population is a new mouse resource derived from partially
inbred Collaborative Cross strains and maintained by randomized outcrossing. As such, it …

Problematic alcohol use (PAU) is a leading cause of death and disability worldwide. Although
genome-wide association studies have identified PAU risk genes, the genetic architecture …

Cannabis use is a heritable trait that has been associated with adverse mental health outcomes.
In the largest genome-wide association study (GWAS) for lifetime cannabis use to date (…

Rationale Caffeine is widely consumed in foods and beverages and is also used for a variety
of medical purposes. Despite its widespread use, relatively little is understood regarding …

Objective: Alcohol use disorders are common conditions that have enormous social and
economic consequences. Genome-wide association analyses were performed to identify …

Importance Neuroticism is a pervasive risk factor for psychiatric conditions. It genetically
overlaps with major depressive disorder (MDD) and is therefore an important phenotype for …

We previously reported a genomewide scan to identify autism-susceptibility loci in 110
multiplex families, showing suggestive evidence (P < .01) for linkage to autism-spectrum …