Instability in the composition of gut bacterial communities (dysbiosis) has been linked to
common human intestinal disorders, such as Crohn’s disease and colorectal cancer. Here, we …

To explore the role of homeobox genes in the intestine, the human colon adenocarcinoma
cell line Caco2-TC7 has been stably transfected with plasmids synthesizing Cdx1 and Cdx2 …

Stem cells underlie tissue homeostasis, but their dynamics during ageing—and the relevance
of these dynamics to organ ageing—remain unknown. Here we report that the expression …

The analysis of mutant mice is bringing novel insights on the role of extracellular matrix (ECM)
and integrin receptors during a variety of physiological processes, including embryonic …

Integrins α6β1 and α6β4 are cell surface receptors for laminins. Integrin α6-null mice die at
birth with severe skin blistering and defects in the cerebral cortex and in the retina. Integrin …

Background— Laminins are major components of basement membranes, well located to
interact with platelets upon vascular injury. Laminin-111 (α 1 β 1 γ 1 ) is known to support …

Metastatic dissemination of cancer cells, which accounts for 90% of cancer mortality, is the
ultimate hallmark of malignancy. Growing evidence suggests that blood platelets have a …

Fascin-1 is an actin-bundling protein that contributes to the architecture and function of cell
protrusions and microfilaments in cell adhesion, interactions and motility. Fascin-1 has been …

Objective Epidemiological and clinical data indicate that patients suffering from IBD with
long-standing colitis display a higher risk to develop colorectal high-grade dysplasia. Whereas …

During development, Schwann cells extend lamellipodia-like processes to segregate large-
and small-caliber axons during the process of radial sorting. Radial sorting is a prerequisite …