Genetic changes causing brain size expansion in human evolution have remained elusive.
Notch signaling is essential for radial glia stem cell proliferation and is a determinant of …

Throughout evolution primate genomes have been modified by waves of retrotransposon
insertions 1 , 2 , 3 . For each wave, the host eventually finds a way to repress retrotransposon …

Somatic LINE-1 (L1) retrotransposition during neurogenesis is a potential source of genotypic
variation among neurons. As a neurogenic niche, the hippocampus supports pronounced …

Using high-throughput sequencing, we devised a technique to determine the insertion sites
of virtually all members of the human-specific L1 retrotransposon family in any human …

The detection of somatic mutations from cancer genome sequences is key to understanding
the genetic basis of disease progression, patient survival and response to therapy. …

L1 retrotransposons comprise 17% of the human genome and are its only autonomous mobile
elements. Although L1-induced insertional mutagenesis causes Mendelian disease, their …

Transposable elements (TEs) drive genome evolution and are a notable source of
pathogenesis, including cancer. While CpG methylation regulates TE activity, the locus-specific …

Somatic L1 retrotransposition events have been shown to occur in epithelial cancers. Here,
we attempted to determine how early somatic L1 insertions occurred during the development …

The number of software tools available for detecting transposable element insertions from
whole genome sequence data has been increasing steadily throughout the last ~5 years. …

High-throughput sequencing has recently begun to revolutionize the study of structural variants
in the genomes of humans and other species. More recently, this technology and others …