User profiles for Adam D. Kashlan

Adam Kashlan

FM Kirby Neurobiology Center, Boston Children's Hospital
Verified email at gatech.edu
Cited by 114

DeepEthogram, a machine learning pipeline for supervised behavior classification from raw pixels

…, YY Dai, DA Yarmolinsky, T Cruz, AD Kashlan… - Elife, 2021 - elifesciences.org
Videos of animal behavior are used to quantify researcher-defined behaviors of interest to
study neural function, gene mutations, and pharmacological therapies. Behaviors of interest …

Development and validation of painface, a software platform that simplifies and standardizes mouse grimace analyses

…, LV Lima, SG Sotocinal, JS Austin, AD Kashlan… - The Journal of …, 2023 - Elsevier
Facial grimaces are now commonly used to quantify spontaneous pain in mice and other
mammalian species, but scoring remains subjective and relies on humans with very different …

Development and validation of PainFace, a software platform that simplifies and standardizes mouse grimace analyses

…, LV Lima, SG Sotocinal, JS Austin, AD Kashlan… - bioRxiv, 2022 - biorxiv.org
Facial grimaces are now commonly used to quantify spontaneous pain in mice and other
mammalian species, but scoring remains subjective and relies on humans with very different …

Development of PainFace software to simplify, standardize, and scale up mouse grimace analyses

…, LV Lima, SG Sotocinal, JS Austin, AD Kashlan… - Pain, 2022 - journals.lww.com
Facial grimacing is used to quantify spontaneous pain in mice and other mammals, but
scoring relies on humans with different levels of proficiency. Here, we developed a cloud-based …

Lhs1 dependent ERAD is determined by transmembrane domain context

…, S Shi, TR Kleyman, OB Kashlan… - Biochemical …, 2023 - portlandpress.com
Transmembrane proteins have unique requirements to fold and integrate into the endoplasmic
reticulum (ER) membrane. Most notably, transmembrane proteins must fold in three …

Parabrachial Hyperexcitability In A Mouse Model Of Neuropathic Pain

MT Suarez, N Cramer, B Neugebauer, K Flores-Felix… - The Journal of …, 2023 - Elsevier
The parabrachial nucleus (PBN) is an important sensory processing and relay station for
pain neurotransmission. Data from in vivo and histological studies have shown that PBN …

Epithelial Na+ channel regulation by cytoplasmic and extracellular factors

OB Kashlan, TR Kleyman - Experimental cell research, 2012 - Elsevier
Electrogenic Na + transport across high resistance epithelial is mediated by the epithelial
Na + channel (ENaC). Our understanding of the mechanisms of ENaC regulation has …

Dynamic Role Of Locus Coeruleus Mu Opioid Receptor Function In Nociceptive Processing

M Norris, CC Kuo, J Kim, L Becker, SS Dunn… - The Journal of …, 2023 - Elsevier
Dissecting discrete neural circuitry is critical to understanding how pain processing may be
altered in the transition from acute to chronic, maladaptive pain. The locus coeruleus (LC) …

Multiple motifs regulate apical sorting of p75 via a mechanism that involves dimerization and higher-order oligomerization

…, SA Costa, Y Rbaibi, F Lanni, OB Kashlan… - Molecular biology of …, 2013 - Am Soc Cell Biol
The sorting signals that direct proteins to the apical surface of polarized epithelial cells are
complex and can include posttranslational modifications, such as N- and O-linked …

Reversible electrocochleographic abnormalities in superior canal dehiscence

HA Arts, ME Adams, SA Telian, H El-Kashlan… - Otology & …, 2009 - journals.lww.com
Objective: Electrocochleography (ECoG) is often used in the evaluation of episodic vertigo,
and abnormal findings are commonly thought to be due to endolymphatic hydrops. We have …