User profiles for Adam Frost
 | Adam FrostAltos Labs, University of California, San Francisco, University of Utah Verified email at ucsf.edu Cited by 9302 |
[HTML][HTML] A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress
The conserved transcriptional regulator heat shock factor 1 (Hsf1) is a key sensor of
proteotoxic and other stress in the eukaryotic cytosol. We surveyed Hsf1 activity in a genome-wide …
proteotoxic and other stress in the eukaryotic cytosol. We surveyed Hsf1 activity in a genome-wide …
The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins
10.7554/eLife.37018.001 The endoplasmic reticulum (ER) supports biosynthesis of proteins
with diverse transmembrane domain (TMD) lengths and hydrophobicity. Features in …
with diverse transmembrane domain (TMD) lengths and hydrophobicity. Features in …
Structural basis of mitochondrial receptor binding and constriction by DRP1
…, A Yusuf, PV Thomas, DA Agard, JM Shaw, A Frost - Nature, 2018 - nature.com
Mitochondrial inheritance, genome maintenance and metabolic adaptation depend on
organelle fission by dynamin-related protein 1 (DRP1) and its mitochondrial receptors. DRP1 …
organelle fission by dynamin-related protein 1 (DRP1) and its mitochondrial receptors. DRP1 …
[HTML][HTML] A structural biology community assessment of AlphaFold2 applications
Most proteins fold into 3D structures that determine how they function and orchestrate the
biological processes of the cell. Recent developments in computational methods for protein …
biological processes of the cell. Recent developments in computational methods for protein …
eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response
The integrated stress response (ISR) tunes the rate of protein synthesis. Control is exerted
by phosphorylation of the general translation initiation factor eIF2. eIF2 is a guanosine …
by phosphorylation of the general translation initiation factor eIF2. eIF2 is a guanosine …
[HTML][HTML] Structural basis of membrane invagination by F-BAR domains
BAR superfamily domains shape membranes through poorly understood mechanisms. We
solved structures of F-BAR modules bound to flat and curved bilayers using electron (cryo)…
solved structures of F-BAR modules bound to flat and curved bilayers using electron (cryo)…
[HTML][HTML] The BAR domain superfamily: membrane-molding macromolecules
Membrane-shaping proteins of the BAR domain superfamily are determinants of organelle
biogenesis, membrane trafficking, cell division, and cell migration. An upsurge of research …
biogenesis, membrane trafficking, cell division, and cell migration. An upsurge of research …
GTP-dependent twisting of dynamin implicates constriction and tension in membrane fission
Dynamin, a crucial factor in endocytosis 1 , 2 , 3 , is a member of a family of GTPases that
participates in membrane fission 4 , 5 , 6 . It was initially proposed to act as a machine that …
participates in membrane fission 4 , 5 , 6 . It was initially proposed to act as a machine that …
Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients
Membrane protein biogenesis in the endoplasmic reticulum (ER) is complex and failure-prone.
The ER membrane protein complex (EMC), comprising eight conserved subunits, has …
The ER membrane protein complex (EMC), comprising eight conserved subunits, has …
Membrane fission by dynamin: what we know and what we need to know
…, K Faelber, M Ford, VA Frolov, A Frost… - The EMBO …, 2016 - embopress.org
The large GTP ase dynamin is the first protein shown to catalyze membrane fission. Dynamin
and its related proteins are essential to many cell functions, from endocytosis to organelle …
and its related proteins are essential to many cell functions, from endocytosis to organelle …