SARS-CoV-2, a novel coronavirus (CoV) that causes COVID-19, has recently emerged
causing an ongoing outbreak of viral pneumonia around the world. While distinct from SARS-CoV…

SARS-CoV-2, a novel coronavirus (CoV), has recently emerged causing an ongoing outbreak
of 2 viral pneumonia around the world. While genetically distinct from the original SARS-…

Zika virus (ZIKV) belongs to the family Flaviviridae, and is related to other viruses that cause
human diseases. Unlike other flaviviruses, ZIKV infection can cause congenital neurological …

The innate antiviral response is integral in protecting the host against virus infection. Many
proteins regulate these signaling pathways including ubiquitin enzymes. The ubiquitin-…

Purpose of Review Tripartite motif (TRIM) proteins are a large group of E3 ubiquitin ligases
involved in different cellular functions. Of special interest are their roles in innate immunity, …

Type I interferons (IFN-I) are essential to establish antiviral innate immunity. Unanchored (or
free) polyubiquitin (poly-Ub) has been shown to regulate IFN-I responses. However, few …

The innate immune system responds rapidly to protect against viral infections, but an overactive
response can cause harmful damage. To avoid this, the response is tightly regulated by …

Enteric viruses exploit bacterial components, including lipopolysaccharides (LPS) and
peptidoglycan (PG), to facilitate infection in humans. Because of their origin in the bat enteric …

Ubiquitination of proteins is a post-translational modification process with many different
cellular functions, including protein stability, immune signaling, antiviral functions and virus …

Based on genome-scale loss-of-function screens we discovered that Topoisomerase III-β (TOP3B),
a human topoisomerase that acts on DNA and RNA, is required for yellow fever virus …